Véronique Fischer

SUPT3H-less SAGA coactivator can assemble and function without significantly perturbing RNA polymerase II transcription in mammalian cells

This study shows that SUPT3H is not essential for SAGA complex assembly or overall Pol II transcription but is required for mESC growth and self-renewal.

OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency

The paper identifies a genetic circuitry where OCT4 activates an antisense lncRNA that represses Suv39h1, linking H3K9 methylation levels to pluripotency in mouse ES cells.

Histone H2Bub1 deubiquitylation is essential for mouse development, but does not regulate global RNA polymerase II transcription

This study shows that USP22 and ATXN7L3 are essential for mouse development, with distinct roles, and that H2Bub1 deubiquitylation does not globally regulate RNA polymerase II transcription.