Roberta Marongiu

Microglial sTREM2 limits dyskinesia and acts on TrkB to support circuit plasticity

The paper identifies a microglial gene program linked to dyskinesia in Parkinson's disease and shows that sTREM2 reduces dyskinesia by modulating TrkB signaling and synaptic plasticity.

A Versatile AAV-TH-SNCA Model to Study Early α-Synuclein Pathology and Intervention

This paper develops an optimized AAV.TH.SNCA model to study early α-synuclein pathology in mice, showing that motor deficits and neurochemical changes occur before neuronal loss.

Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson's Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior Disorder

This study shows that gut-to-brain propagation of alpha-synuclein fibrils induces REM sleep behavior disorder and other non-motor and motor Parkinson's disease phenotypes.

Non-invasive in vivo bidirectional magnetogenetic modulation of pain circuits.

This paper introduces a magnetogenetic method to bidirectionally control pain circuits in mice using magnetic fields and a fusion protein, showing both excitatory and inhibitory effects on nociceptor activity.

Perimenopause promotes neuroinflammation in select hippocampal regions in a mouse model of Alzheimers disease

This study shows that perimenopause increases Aβ aggregation and glial activation in specific hippocampal regions in female 5xFAD mice, but not cognitive deficits.

Bidirectional Regulation of Motor Circuits Using Magnetogenetic Gene Therapy

This paper develops magnetogenetic tools to bidirectionally regulate specific neuronal circuits in vivo using magnetic fields and shows their efficacy in motor control and Parkinson's models.