Author
Weill Cornell MedicineORCID 0000-0002-8979-2459Unclaimed ORCID profile · follow to get notified of new preprints
7 papers
Recent·Most cited
Alexandros C. Kokotos, Santiago René Unda, Paula Reyes‐Pérez, Mariam Isayan, María Teresa Periñán, Michael G. Kaplitt, Timothy A. Ryan
This study identifies NDK as a key gene at the intersection of guanosine nucleotide metabolism and bioenergetics, showing its protective role in Parkinson's disease and its association with genetic risk.
bioRxiv · Aug 10, 2026 · PreprintNeuroscience
Caitlin Castagnola, Roberta Marongiu, Yuansong Wan, Eileen Ruth Torres, Li Fan, Minwoo Wendy Jang, Qiaoling Cui, Jihye Kim, Pearly Ye, Jingjie Zhu, Alisa Panichkina, Alexandra B. Fall, Kendra Norman, Beichen Gao, Nessa R. Foxe, , Li Gan
The paper identifies a microglial gene program linked to dyskinesia in Parkinson's disease and shows that sTREM2 reduces dyskinesia by modulating TrkB signaling and synaptic plasticity.
bioRxiv · May 7, 2026 · PreprintNeuroscience
Sabina Marciano, Leandra G. Velazquez, Claudia Rodríguez López, Neranjan de Silva, Garrett Sommer, William Tower, Eileen Ruth S. Torres, Michael G. Kaplitt, Teresa A. Milner, Roberta Marongiu
This paper develops an optimized AAV.TH.SNCA model to study early α-synuclein pathology in mice, showing that motor deficits and neurochemical changes occur before neuronal loss.
bioRxiv · Apr 30, 2026 · PreprintNeuroscience
Daniel Dautan, Wojciech Pasławski, Sergio Montejo, Daniel C. Doyon, Valentina I. Brioschi, Roberta Marongiu, Michael G. Kaplitt, Rong Chen, Valina Lynn Dawson, Xiaoqun Zhang, Ted M. Dawson, Per Svenningsson
This study shows that gut-to-brain propagation of alpha-synuclein fibrils induces REM sleep behavior disorder and other non-motor and motor Parkinson's disease phenotypes.
Translational Neurodegeneration · Mar 10, 2026Peer-reviewedNeuroscience
Aldana M. Antoniazzi, Santiago René Unda, Sofya Norman, Lisa E. Pomeranz, Roberta Marongiu, Sarah A. Stanley, Jeffrey M. Friedman, Michael G. Kaplitt
This paper introduces a magnetogenetic method to bidirectionally control pain circuits in mice using magnetic fields and a fusion protein, showing both excitatory and inhibitory effects on nociceptor activity.
bioRxiv · Mar 18, 2025 · PreprintNeuroscience
Santiago René Unda, Lisa E. Pomeranz, Roberta Marongiu, Xiaofei Yu, Leah Kelly, Gholamreza Hassanzadeh, Henrik Molina, George Vaisey, Putianqi Wang, Jonathan P. Dyke, Edward K. Fung, Logan Grosenick, Rick T. Zirkel, Aldana M. Antoniazzi, Sofya Norman, , Michael G. Kaplitt
This paper develops magnetogenetic tools to bidirectionally regulate specific neuronal circuits in vivo using magnetic fields and shows their efficacy in motor control and Parkinson's models.
Science Advances · Oct 9, 2024Peer-reviewedNeuroscience
Alexandros C. Kokotos, Aldana M. Antoniazzi, Santiago René Unda, Myung Soo Kokotos, Daehun Park, David Eliezer, Michael G. Kaplitt, Pietro V. De Camilli, Timothy A. Ryan
The paper identifies PGK1 as a rate-limiting enzyme in axonal metabolism and shows its protective role against Parkinson's disease-related synaptic deficits.
Science Advances · Aug 21, 2024Peer-reviewedNeuroscience