Author

Francis E. Sharkey

The University of Texas at San Antonio Health Science CenterORCID 0000-0002-7398-3285Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Pei WangiD· 3 shared Yi XuiD· 2 shared Angel A. Dominguez· 1 shared Chenhui He· 1 shared Daohong ZhouiD· 1 shared Debodipta DasiD· 1 shared Francisco G. CigarroaiD· 1 shared Hakim BouamariD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMolecular Biology

Pei WangORCID

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Author profile →

4 papers

Recent·Most cited

Distinct and shared synergistic effects of high-fat and high-iron diets on liver tumorigenesis and transcriptomic remodeling in mice

Debodipta Das, Hakim Bouamar, Xiaoli Sun, Jason Xu, Lu Cai, Yidong Chen, Francis E. Sharkey, Sukeshi Patel Arora, Francisco G. Cigarroa, Lu‐Zhe Sun

This study examines how high-fat and high-iron diets affect liver tumorigenesis and transcriptomic changes in mice, finding shared and distinct molecular effects.

bioRxiv · May 27, 2026 · PreprintCancer Biology

NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress

Yi Xu, Michael H Nipper, Angel A. Dominguez, Chenhui He, Francis E. Sharkey, Sajid Khan, Han Xu, Daohong Zhou, Lei Zheng, Yu Luan, Jun Liu, Pei Wang

This study identifies NF2 as a critical tumor suppressor in PDAC, showing its role in promoting invasive behavior, enhancing cell fitness under stress, and contributing to drug resistance.

Journal of Clinical Investigation · Jan 1, 2026Peer-reviewedCancer Biology

Exploring the Role of YAP1 and TAZ in Pancreatic Acinar Cells and the Therapeutic Potential of VT-104 in Pancreatic Inflammation

Kevin M Lopez, Janice Deng, Yi Xu, Francis E. Sharkey, Pei Wang, Jun Liu

This study investigates the role of YAP1 and TAZ in pancreatic inflammation and evaluates the therapeutic potential of VT-104 in a mouse model of pancreatitis.

Journal of Pancreatology · Jan 16, 2024Peer-reviewedMolecular Biology

Deletion of Lats 1 and 2 in mouse pancreatic acinar cells induces pancreatic fibrosis and inflammation

Ming Gao, Jun Liu, MICHAEL J. NIPPER, Francis E. Sharkey, Randy L. Johnson, Howard C. Crawford, Yidong Chen, Pei Wang

This study shows that deleting Lats1 and Lats2 in adult mouse pancreatic acinar cells causes fibrosis and inflammation through YAP1/TAZ activation.

bioRxiv · Jan 23, 2019 · PreprintMolecular Biology