Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis
Rosana-Bristena Ionescu, Alexandra M. Nicaise, Julie A. Reisz, Eleanor C Williams, Pranathi Prasad, Cory M. Willis, Madalena B C Simões-Abade, Linda Sbarro, Monika Dzieciątkowska, Daniel Stephenson, Marta Suarez Cubero, Sandra Rizzi, Liviu Pirvan, Luca Peruzzotti‐Jametti, Valentina Fossati, , Stefano Pluchino
This study identifies increased cholesterol synthesis in PMS patient-derived neural progenitor cells as a driver of neurotoxicity, which can be mitigated by simvastatin.
Cell stem cell · Oct 21, 2024Peer-reviewedNeuroscience