Author

Liviu Pirvan

Wellcome/MRC Cambridge Stem Cell InstituteORCID 0000-0003-2425-7778Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1 Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:DNA methylation· 2 Assay:Hi-C· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Shamith SamarajiwaiD· 3 shared Alexandra M. NicaiseiD· 2 shared Cory M. WillisiD· 2 shared Frank EdenhoferiD· 2 shared Irina I MohorianuiD· 2 shared Luca Peruzzotti‐JamettiiD· 2 shared Marta Suarez CuberoiD· 2 shared Pranathi PrasadiD· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCell Biology

Shamith SamarajiwaORCID

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5 papers

Recent·Most cited

Non-catalytic role for MLL2 in controlling chromatin organisation and mobility during priming of pluripotent cells for differentiation

M. Steindel, Oliver Davis, Katrin Neumann, Gökçe G. Agsu, Lingjun Mao, Andrea Kranz, Liviu Pirvan, Dwaipayan Adhya, Jörg Morf, Ziwei Zhang, Shuyue Yang, Jun Fu, Melania Barile, Annabelle Wurmser, Stanley E. Strawbridge, , Srinjan Basu

This study shows MLL2 stabilizes 3D chromatin loops during pluripotent cell differentiation without requiring its enzymatic activity.

bioRxiv · Feb 21, 2025 · PreprintCell Biology

Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

Rosana-Bristena Ionescu, Alexandra M. Nicaise, Julie A. Reisz, Eleanor C Williams, Pranathi Prasad, Cory M. Willis, Madalena B C Simões-Abade, Linda Sbarro, Monika Dzieciątkowska, Daniel Stephenson, Marta Suarez Cubero, Sandra Rizzi, Liviu Pirvan, Luca Peruzzotti‐Jametti, Valentina Fossati, , Stefano Pluchino

This study identifies increased cholesterol synthesis in PMS patient-derived neural progenitor cells as a driver of neurotoxicity, which can be mitigated by simvastatin.

Cell stem cell · Oct 21, 2024Peer-reviewedNeuroscience

Integrative single-cell analysis of neural stem/progenitor cells reveals epigenetically dysregulated interferon response in progressive multiple sclerosis

Bong Soo Park, Alexandra M. Nicaise, Dimitrios Tsitsipatis, Liviu Pirvan, Pranathi Prasad, Miguel Larraz Lopez De Novales, Julia Whitten, Luka Čulig, Joseph Llewellyn, Rosana-Bristena Ionescu, Cory M. Willis, Grzegorz Krzak, Jinshui Fan, Supriyo De, Marta Suarez Cubero, , Isabel Beerman

bioRxiv · Feb 9, 2024 · PreprintNeuroscience

Identifying regulatory and spatial genomic architectural elements using cell type independent machine and deep learning models

Laura D. Martens, Oisín Faust, Liviu Pirvan, Dóra Bihary, Shamith Samarajiwa

The paper develops machine and deep learning models to predict chromatin interactions and TAD boundaries using histone modification data, independent of Hi-C data.

bioRxiv · Apr 19, 2020 · PreprintGenomics

Pangaea: A modular and extensible collection of tools for mining context dependent gene relationships from the biomedical literature

Liviu Pirvan, Shamith Samarajiwa

Pangaea extracts context-dependent gene relationships from biomedical literature using natural language processing and provides scalable, extensible tools for analysis.

bioRxiv · Apr 2, 2020 · PreprintBioinformatics