Author

M. B. Zwick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Assay:cryo-EM· 2 Approach:experimental assay· 2 Approach:microscopy & imaging analysis· 2 Organism:virus· 2 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

D. P. Leaman· 2 shared L. Zhang· 2 shared A. Antanasijevic· 1 shared A. Irimia· 1 shared A. Stano· 1 shared A. Ward· 1 shared C. A. Schramm· 1 shared E. A. Hodge· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiophysics

D. P. Leaman

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Author profile →

4 papers

Recent·Most cited

Asymmetric HIV-1 envelope trimers bound to one and two CD4 molecules are intermediates during membrane binding

W. Li, E. Nand, Z. Qin, M. W. Grunst, J. R. Grover, J. W. Bess, J. D. Lifson, M. B. Zwick, H. D. Tagare, P. D. Uchil, W. Mothes

The paper uses cryo-ET to study HIV-1 Env-CD4 interactions on membranes, revealing asymmetric trimers bound to one or two CD4 molecules as intermediates in virus binding.

bioRxiv · Dec 23, 2022Microbiology

Cryo-ET of HIV reveals Env positioning on Gag lattice and structural variation among Env trimers

V. Mangala Prasad, D. P. Leaman, K. N. Lovendahl, J. T. Croft, M. A. Benhaim, E. A. Hodge, M. B. Zwick, K. K. Lee

This study uses cryo-ET to analyze HIV-1 Env structure and positioning in mature and immature virions, revealing structural variation and insights into Env incorporation and antigen presentation.

bioRxiv · Aug 31, 2021Biophysics

Membrane Env liposomes for immunization with HIV spikes

D. P. Leaman, A. Stano, Y. Chen, L. Zhang, M. B. Zwick

This study develops mEnv liposomes (MELs) as a vaccine platform that elicits HIV broadly neutralizing antibodies without extra proteins, showing neutralization of tier 2 HIV isolates in rabbits.

bioRxiv · Nov 29, 2020 · PreprintImmunology

HIV-1 Envelope and MPER antibody structures in lipid assemblies

K. Rantalainen, Z. T. Berndsen, A. Antanasijevic, T. Schiffner, X. Zhang, W.-H. Lee, J. L. Torres, L. Zhang, A. Irimia, J. Copps, K. Zhou, Y. D. Kwon, W. H. Law, C. A. Schramm, R. Verardi, , A. Ward

This study presents methods to incorporate full-length HIV-1 Env into lipid assemblies for structural analysis, revealing the quaternary epitope of an MPER antibody and Env tilting during neutralization.

bioRxiv · Nov 15, 2019Immunology