A. Singhi

Therapeutic potential of SOX9 dysruption in Combined Hepatocellular Carcinoma-Cholangiocarcinoma

This study contrasts the effects of developmental and acute Sox9 deletion in cHCC-CCA models, showing that Sox9 elimination can reduce tumor burden and highlights therapeutic potential.

β-Catenin-NFκB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction

This study identifies a β-catenin-NFκB-CFTR interactome in cholangiocytes that regulates inflammation and fibrosis during ductular reaction in liver disease.

NOTCH-YAP1/TEAD-DNMT1 axis regulates hepatocytereprogramming into intrahepatic cholangiocarcinoma

The paper identifies a NOTCH-YAP1/TEAD-DNMT1 axis that drives hepatocyte reprogramming into intrahepatic cholangiocarcinoma and reveals its role in tumor development.

Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors

This study shows YAP1 is essential for bile duct development and reveals hepatocyte adaptation in its absence.

Detection of Chemotherapy-Resistant Pancreatic Cancer Using a Glycan Biomarker

This paper identifies sTRA as a glycan biomarker for chemotherapy-resistant pancreatic cancer, showing its presence correlates with poor treatment response in multiple systems.

Paradoxical role of AT-rich interactive domain 1A in restraining pancreatic carcinogenesis

This study investigates the role of Arid1a in pancreatic carcinogenesis using mouse models and cell lines, finding that its loss impairs tumor growth and DNA repair but allows for later aggressive cancer development.

Petite Integration Factor 1 (PIF1) helicase deficiency increases weight gain in Western diet-fed female mice without increased inflammatory markers or decreased glucose clearance

This study shows that PIF1 helicase deficiency in female mice on a Western diet leads to increased weight gain but not inflammation or reduced glucose clearance.