M. Iwasaki

An mRNA-LNP-based Lassa virus vaccine induces protective immunity in mice

This study shows that mRNA-LNP vaccines against Lassa virus protect mice from lethal infection, inducing strong CD8+ T cell responses without significant antibody production.

Two unique biological response-modifier glucans beneficially regulating gut microbiota and faecal metabolome in a non-alcoholic steatohepatitis animal model, with potential for applications in human health and disease

This study evaluates the effects of two glucans on gut microbiota and metabolome in a NASH model, showing beneficial changes in microbial composition and metabolite levels.

IFNA pathway drives the more aggressive phenotype of KRASG12D-mutant pancreatic ductal adenocarcinomas via IFNAR1/STAT3 activation

The paper shows that the IFNA pathway promotes aggressive KRASG12D-mutant pancreatic ductal adenocarcinomas through IFNAR1/STAT3 activation and identifies IFNAR1 inhibition as a potential therapeutic strategy.

A stress-reduced passaging technique improves the viability of human pluripotent cells

This paper introduces a stress-reduced passaging technique for human pluripotent stem cells that improves viability and downstream application efficiency without altering cell characteristics.

pSNAP: Proteome-wide analysis of elongating nascent polypeptide chains

pSNAP profiles proteome-wide elongating nascent polypeptide chains, revealing translational repression and modification effects on ribosome-associated interactions.

An efficient polymer cocktail-based transportation method for cartilage tissue, yielding chondrocytes with enhanced hyaline cartilage expression during in vitro culturing

This study compares two transport methods for cartilage tissue, finding that a thermo-reversible gelation polymer (TGP) based method yields higher cell counts and better hyaline cartilage gene expression than Euro-Collins solution.

Hepatoprotective effects of Aureobasidium pullulans derived Beta 1,3-1,6 biological response modifier glucans in a STAM- animal model of non-alcoholic steatohepatitis

This study evaluates the hepatoprotective effects of two Aureobasidium pullulans beta glucans in a NASH mouse model, showing reduced inflammation and fibrosis.