Author

M. J. Henderson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. J. Marugan· 3 shared A. Kapoor· 2 shared A. Simeonov· 2 shared A. Wang· 2 shared X. Xu· 2 shared A. E. Owens· 1 shared A. Gehrlein· 1 shared A. Glogowska· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersPharmacology & Toxicology

J. J. Marugan

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Author profile →

4 papers

Recent·Most cited

Development of quantitative high-throughput screening assays to identify, validate, and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase with therapeutic potential for Gaucher disease and Parkinson's disease

D. Williams, L. M. Glasstetter, T. T. Jong, A. Kapoor, S. Zhu, Y. Zhu, A. Gehrlein, D. J. Vocadlo, R. Jagasia, J. J. Marugan, E. Sidransky, M. J. Henderson, Y. Chen

This paper develops high-throughput assays to identify and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase, showing NCGC326 reverses pathological accumulation and synergizes with proteostasis regulators.

bioRxiv · Mar 22, 2024 · PreprintPharmacology & Toxicology

Overcoming brain-derived therapeutic resistance in HER2+ breast cancer brain metastasis

D. Ippolitov, Y.-H. Lin, J. Spence, A. Glogowska, T. Thanasupawat, J. Beiko, M. R. Del Bigio, X. Xu, A. Wang, R. Calvo, A. Kapoor, J. J. Marugan, M. J. Henderson, T. Klonisch, S. Hombach-Klonisch

This study establishes a patient-derived HER2+ brain metastasis model and identifies Poziotinib as an effective RTKi for treating HER2+ breast cancer brain metastasis in mice.

bioRxiv · Feb 19, 2024 · PreprintCancer Biology

A real-time cellular thermal shift assay (RT-CETSA) to monitor target engagement

T. W. Sanchez, M. H. Ronzetti, A. E. Owens, M. Antony, T. Voss, E. Wallgren, D. Talley, K. Balakrishnan, G. Rai, J. J. Marugan, S. Michael, B. Baljinnyam, N. Southall, A. Simeonov, M. J. Henderson

The paper introduces RT-CETSA, a real-time cellular thermal shift assay that improves throughput and sensitivity for monitoring ligand-target engagement in cells.

bioRxiv · Jan 24, 2022 · PreprintPharmacology & Toxicology

Assessing Inhibitors Of Mutant Isocitrate Dehydrogenase Using A Suite Of Pre-Clinical Discovery Assays

D. J. Urban, N. J. Martinez, M. I. Davis, K. R. Brimacombe, D. M. Cheff, T. D. Lee, M. J. Henderson, S. A. Titus, R. Pragani, J. M. Rohde, Y. Wang, S. Karavadhi, P. Shah, O. W. Lee, A. Wang, , M. D. Hall

The paper evaluates inhibitors of mutant IDH1 and IDH2 using biochemical and cell-based assays to identify effective compounds for cancer therapy.

bioRxiv · Apr 7, 2017Cancer Biology