Author

M. Kaforou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:differential expression· 4 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

M. Levin· 3 shared C. Broderick· 2 shared E. Adem· 2 shared I. Muller· 2 shared J. A. Cotton· 2 shared P. Kropf· 2 shared R. Womersley· 2 shared S. U. Franssen· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersImmunology

M. Levin

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Author profile →

6 papers

Recent·Most cited

Comparative transcriptomic analysis of whole blood mycobacterial growth assays and tuberculosis patients' blood RNA profiles

P. Bachanova, A. Cheyne, C. Broderick, S. M. Newton, M. Levin, M. Kaforou

The paper compares gene expression in an in vitro whole blood Mtb infection model with tuberculosis patients' blood, identifying concordant and discordant immune responses and their drivers.

bioRxiv · Jun 24, 2022Immunology

The altered entry pathway and antigenic distance of the SARS-CoV-2 Omicron variant map to separate domains of spike protein

T. P. Peacock, J. C. Brown, J. Zhou, N. Thakur, K. Sukhova, J. Newman, R. Kugathasan, A. W. C. Yan, W. Furnon, G. De Lorenzo, V. M. Cowton, D. Reuss, M. Moshe, O. K. Platt, J. L. Quantrill, , W. S. Barclay

This study identifies distinct genetic determinants in the Omicron spike protein for altered cell entry and antigenic properties, showing they are separable and may affect future variant severity and vaccine efficacy.

bioRxiv · Dec 31, 2021 · PreprintMicrobiology

Impaired in vitro Interferon-γ production in patients with visceral leishmaniasis is improved by inhibition of PD1/PDL-1 ligation

Y. Takele, E. Adem, S. U. Franssen, R. Womersley, M. Kaforou, M. Levin, I. Muller, J. A. Cotton, P. Kropf

This study shows that PD1/PDL-1 inhibition increases IFN-γ production in VL patients, suggesting potential for immune checkpoint therapy.

bioRxiv · Nov 1, 2021Immunology

Immunological factors, but not clinical features, predict visceral leishmaniasis relapse in patients co-infected with HIV

Y. Takele, T. Mulaw, E. Adem, C. J. Shaw, S. U. Franssen, R. Womersley, M. Kaforou, G. P. Taylor, M. Levin, I. Muller, J. A. Cotton, P. Kropf

The paper identifies three immunological markers that predict visceral leishmaniasis relapse in HIV co-infected patients, showing they are more predictive than clinical features.

bioRxiv · Mar 30, 2021Immunology

Host transcriptional response to TB preventive therapy differentiates two sub-groups of IGRA-positive individuals

C. Broderick, J. M. Cliff, J.-S. Lee, M. Kaforou, D. A. Moore

The paper analyzes transcriptional responses to tuberculosis preventive therapy in IGRA-positive individuals, identifying two subgroups with distinct gene expression patterns linked to Mtb viability.

bioRxiv · Jul 20, 2020Immunology

Shigella sonnei infection of zebrafish reveals that O-antigen mediates neutrophil tolerance and dysentery incidence

V. Torraca, M. Kaforou, J. Watson, G. M. Duggan, H. Guerrero-Gutierrez, S. Krokowski, M. Hollinshead, T. B. Clarke, R. J. Mostowy, G. S. Tomlinson, V. Sancho-Shimizu, A. Clements, S. Mostowy

This paper shows that Shigella sonnei's O-antigen mediates neutrophil tolerance and increases dysentery incidence in zebrafish, suggesting O-antigen as a therapeutic target.

PLOS Pathogens · Dec 12, 2019Peer-reviewedMicrobiology