M. Lawrence

Continuous Infusion of the CXCR4 Antagonist Plerixafor for WHIM Syndrome

This study evaluates continuous subcutaneous plerixafor infusion in WHIM syndrome patients, showing improved leukocyte counts, wart regression, and patient preference over daily injections.

Functional lung imaging identifies peripheral ventilation changes in mice with muco-obstructive lung disease

This study uses X-ray Velocimetry to identify peripheral ventilation changes in a mouse model of muco-obstructive lung disease.

Mesoscale DNA Features Impact APOBEC3A and APOBEC3B Deaminase Activity and Shape Tumor Mutational Landscapes

This study identifies how mesoscale DNA features influence APOBEC3A and APOBEC3B deaminase activity and their impact on tumor mutational landscapes.

Colorectal cancer detection and treatment with engineered probiotics

This paper demonstrates the use of engineered probiotics to detect and treat colorectal cancer by monitoring their colonization and delivering therapeutic molecules.

In the Line of Fire: Debris Throwing by Wild Octopuses

This study documents nonhuman throwing behavior in wild octopuses, showing targeted throws with social implications and specific behavioral patterns.

Aneuploidy and deregulated DNA damage response define haploinsufficiency in breast tissues of BRCA2 mutation carriers

The paper identifies sub-chromosomal copy number variations and DNA damage in BRCA2 mutation carriers' breast tissues, indicating haploinsufficiency and early carcinogenic changes.

A post-transcriptional program of chemoresistance by AU-rich elements and TTP

This study identifies a post-transcriptional mechanism of chemoresistance in leukemia involving AU-rich elements and TTP regulation.