Author

M. McDonald

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Cancer Biology· 1 Cell Biology· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 4 Assay:whole-genome sequencing· 3 Organism:bacteria (other)· 2 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:fungi (other)· 2

Frequent Co-Authors

B. J. Willett· 2 shared M. J. Hosie· 2 shared P. R. Murcia· 2 shared W. Weir· 2 shared A. Bansal· 1 shared A. Bean· 1 shared A. Brice· 1 shared A. C. Filipe· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersImmunology

B. J. Willett

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Functional whole genome screen of nutrient-starved Mycobacterium tuberculosis identifies genes involved in antibiotic tolerance

W. M. Matern, H. T. Harris, C. Danchik, M. McDonald, G. Patel, A. Srivastava, T. R. Ioerger, J. Bader, P. C. Karakousis

This study identifies Mtb genes involved in antibiotic tolerance under nutrient-starved conditions through a functional genome screen, revealing potential therapeutic targets.

bioRxiv · Apr 12, 2023 · PreprintMicrobiology

Remote neuronal activity drives glioma infiltration via Sema4f

E. Huang-Hobbs, Y.-T. Cheng, Y. Ko, E. Luna-Figueroa, B. Lozzi, K. Taylor, M. McDonald, P. He, H.-C. Chen, Y. Yang, E. Maleki, Z.-F. Lee, S. Murali, M. Williamson, D. Choi, , B. Deneen

This study identifies callosal projection neurons as drivers of glioma infiltration through Sema4F-mediated activity-dependent signaling in mouse and human tumors.

bioRxiv · Mar 15, 2023 · PreprintCancer Biology

Rising SARS-CoV-2 Seroprevalence and Patterns of Cross-Variant Antibody Neutralization in UK Domestic Cats

G. B. Tyson, S. Jones, N. Logan, M. McDonald, P. R. Murcia, B. J. Willett, W. Weir, M. J. Hosie

The paper examines SARS-CoV-2 seroprevalence and cross-variant antibody neutralization in UK domestic cats, finding a 3.2% overall seroprevalence with variant-specific responses correlating with human circulation patterns.

bioRxiv · Nov 18, 2022 · PreprintImmunology

Treatment history shapes the evolution of complex carbapenem-resistant phenotypes in Klebsiella spp.

T. Lithgow, T. Zhou, M. MCDONALD, N. Rosas, J. Wilksch, J. Barber, J. Li, Y. Wang, Z. Sun, A. Rocker, C. Webb, L. Perlaza-Jimenez, C. Stubenrauch, D. Vijaykrishn, J. Song, , Q. Bao

This study shows that treatment history influences the evolution of carbapenem resistance in Klebsiella by shaping the genetic loci involved and their fitness costs.

bioRxiv · Aug 30, 2022Microbiology

Long-term experimental evolution decouples size and production costs in Escherichia coli

D. Marshall, M. Malerba, T. Lines, A. Sezmis, C. Hasan, R. Lenski, M. McDonald

This study shows that in Escherichia coli, larger cell size does not correlate with increased production costs, contradicting metabolic theory predictions.

bioRxiv · Sep 28, 2021 · PreprintEvolutionary Biology

ILRUN downregulates ACE2 expression and blocks infection of human cells by SARS-CoV-2

L. Tribolet, M. Alexander, A. Brice, P. Jansen Van Vuren, C. Rootes, K. Mara, M. McDonald, K. Bruce, T. Gough, S. Shi, C. Cowled, A. Bean, C. R. Stewart

This study shows that ILRUN inhibits SARS-CoV-2 replication by downregulating ACE2 expression and blocking viral entry into human cells.

bioRxiv · Nov 13, 2020Cell Biology

Respiratory disease in cats associated with human-to-cat transmission of SARS-CoV-2 in the UK

M. J. Hosie, I. Epifano, V. Herder, R. Orton, A. Stevenson, N. Johnson, E. MacDonald, D. Dunbar, M. McDonald, F. Howie, B. Tennant, D. Herrity, A. C. Filipe, D. G. Streicker, B. J. Willett, , COVID-19 Genomics UK Consortium

This study reports two cases of SARS-CoV-2 infection in UK cats linked to human-to-cat transmission, showing mild to severe respiratory disease and genetic variation in the viral genome.

bioRxiv · Sep 23, 2020 · PreprintMicrobiology

Remarkable recent changes in genetic diversity of the avirulence gene AvrStb6 in global populations of the wheat pathogen Zymoseptoria tritici

C. Stephens, F. Olmez, H. Blyth, M. McDonald, A. Bansal, E. B. Turgay, F. Hahn, C. Saintenac, V. Nekrasov, P. Solomon, A. Milgate, B. Fraaije, J. J. Rudd, K. Kanyuka

The paper analyzes changes in AvrStb6 genetic diversity in Zymoseptoria tritici isolates from 2013-2017, finding a loss of the original avirulence isoform and dominance of a single virulence isoform.

bioRxiv · Sep 18, 2020Microbiology

Variation and inheritance of the Xanthomonas gene cluster required for activation of XA21-mediated immunity

F. Liu, M. McDonald, B. Schwessinger, A. Joe, R. Pruitt, T. Erickson, X. Zhao, V. Stewart, P. Ronald

The paper identifies the raxX-raxSTAB gene cluster in Xanthomonas species and shows its role in RaxX peptide production, which is required for XA21-mediated immunity but not for peptide hormone activity.

bioRxiv · Oct 19, 2018Microbiology