P. C. Karakousis

Pharmacological inhibition of macrophage triglyceride biosynthesis pathways does not improve Mycobacterium tuberculosis control in infected mice

This study evaluates two compounds that reduce triglyceride content in Mtb-infected macrophages but finds they do not reduce bacterial burden or inflammation in infected mice.

The heme oxygenase-1 metalloporphyrin inhibitor stannsoporfin enhances the bactericidal activity of a novel regimen for multidrug-resistant tuberculosis in a murine model

This paper evaluates the adjunctive effect of the HO-1 inhibitor stannsoporfin in combination with a novel MDR-TB regimen in a murine model, showing reduced lung bacillary burden but no effect on microbiological relapse.

Functional whole genome screen of nutrient-starved Mycobacterium tuberculosis identifies genes involved in antibiotic tolerance

This study identifies Mtb genes involved in antibiotic tolerance under nutrient-starved conditions through a functional genome screen, revealing potential therapeutic targets.

Metabolic switching and cell wall remodelling of Mycobacterium tuberculosis during bone tuberculosis

This study identifies transcriptomic changes and virulence factors in Mycobacterium tuberculosis during bone tuberculosis, revealing metabolic shifts and cell wall remodeling strategies for survival in the host.

Sex differences in lung imaging and SARS-CoV-2 antibody responses in a COVID-19 golden Syrian hamster model

This study shows that male golden Syrian hamsters experience more severe lung disease and lower antiviral antibody responses compared to females after SARS-CoV-2 infection.

Genetic determinants of intrinsic antibiotic tolerance in Mycobacterium avium

This study identifies antibiotic tolerance genes in Mycobacterium avium through a genome-wide transposon screen, revealing potential targets for improving treatment of MAC infections.

Identifying the essential genes of Mycobacterium avium subsp. hominissuis with Tn-Seq using a rank-based filter procedure.

This study identifies essential genes in Mycobacterium avium subsp. hominissuis using Tn-Seq and a rank-based filter, finding 270 essential features overlapping with those in Mycobacterium tuberculosis.

Antibiotic treatment shapes antigen presentation during chronic TB infection, offering novel targets for therapeutic vaccination

This study shows that antibiotic treatment alters antigen presentation during TB, and therapeutic vaccination targeting RelMtb enhances isoniazid efficacy against Mtb persisters.