K. S. Williams

13C metabolite tracing reveals glutamine and acetate as critical in vivo fuels for CD8+ T cells

This study uses 13C-labeled metabolites to show CD8+ T cells switch from glutamine to acetate metabolism during infection.

Ketolysis is a metabolic driver of CD8+ T cell effector function through histone acetylation

This study identifies ketone bodies as essential for CD8+ T cell metabolism and effector function through histone acetylation regulation.

An autonomous mathematical model for the mammalian cell cycle

The paper develops an autonomous mathematical model of the mammalian cell cycle using 13 nonlinear ODEs, showing how growth factors and control mechanisms regulate cycle progression and prevent rereplication.

A non-canonical role for glutamate decarboxylase 1 in cancer cell amino acid homeostasis, independent of the GABA shunt.

This study identifies a non-canonical role for GAD1 in cancer cell amino acid homeostasis, independent of the GABA shunt, by regulating amino acid transporter expression.

Repression of LKB1 by miR-17~92 sensitizes MYC-dependent lymphoma to biguanide treatment

The paper shows that miR-17~92 expression in Myc+ tumors increases sensitivity to biguanide treatment by disrupting bioenergetic stability in lymphoma cells.

Neuroinflammation and EIF2 signaling persist in an HiPSC tri-culture model of HIV infection despite antiretroviral treatment

This study uses a HiPSC tri-culture model to show that HIV infection and antiretroviral treatment persistently affect neuroinflammation and EIF2 signaling in the CNS.

Low-intensity environmental education can enhance perceptions of culturally taboo wildlife

This study tests if low-intensity environmental education improves perceptions of owls, which are culturally taboo due to witchcraft associations, and increases willingness to participate in rodent management schemes.