Author

M. S. Eram

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

C. H. Arrowsmith· 2 shared D. Barsyte-Lovejoy· 2 shared F. Li· 2 shared M. Vedadi· 2 shared P. J. Brown· 2 shared R. Al-Awar· 2 shared B. M. Watson· 1 shared C. A. Zepeda-Velazquez· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersBiochemistry

C. H. Arrowsmith

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Author profile →

2 papers

Recent·Most cited

A First-in-class, Highly Selective and Cell-active AllostericInhibitor of Protein Arginine Methyltransferase 6 (PRMT6)

Y. Shen, F. Li, M. Szewczyk, L. Halabelian, I. Chau, M. S. Eram, C. Dela Sena, K.-S. Park, F. Meng, H. Chen, H. Zeng, D. McLeod, C. A. Zepeda-Velazquez, R. M. Campbell, M. M. Mader, , J. Jin

This paper reports the discovery of a first-in-class, highly selective allosteric inhibitor of PRMT6, SGC6870, with potent activity and selectivity in vitro and in cells.

bioRxiv · Dec 4, 2020 · PreprintBiochemistry

Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response

M. M. Szewczyk, Y. Ishikawa, S. Organ, N. Sakai, F. Li, S. Ackloo, M. S. Eram, D. Dilworth, H. Fukushi, R. Harding, C. C. dela Sena, T. Sugo, K. Hayashi, D. Macleod, C. Zepeda, , D. Barsyte-Lovejoy

This study identifies a PRMT7 inhibitor and shows its effect on arginine methylation of stress proteins, linking PRMT7 to cellular stress response.

bioRxiv · Mar 15, 2019Biochemistry