M. Aggarwal

Synergistic Hypoxia and Apoptosis Conditioning Unleashes Superior Mesenchymal Stem Cells Efficacy in Acute Graft-versus-Host-Disease

This study shows that hypoxia and apoptosis conditioning of WJ-MSCs enhances their immune regulatory capacity in aGVHD by promoting Treg differentiation and M2 macrophage polarization.

Influenza A virus resistance to 4-fluorouridine coincides with viral attenuation in vitro and in vivo

This study identifies mutations conferring resistance to 4-fluorouridine in influenza viruses and shows that resistant variants are attenuated in vivo and can be overcome by higher drug doses.

4-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

This study shows 4-Fluorouridine effectively treats seasonal and highly pathogenic influenza viruses in cell culture, organoids, and animal models, preventing lethal infection and transmission.

Selective estrogen receptor modulators limit alphavirus infection by targeting the viral capping enzyme nsP1

This study shows that SERMs inhibit alphavirus infection by targeting the viral capping enzyme nsP1, with antiviral effects observed in cell culture and mice.

4'-Fluorouridine is a broad-spectrum orally efficacious antiviral blocking respiratory syncytial virus and SARS-CoV-2 replication

This paper identifies 4'-Fluorouridine as an orally effective antiviral that inhibits RSV and SARS-CoV-2 replication in vivo.

The Kamin Blocking Effect in Sign and Goal Trackers

This study investigates the Kamin blocking effect in rats, finding that only sign trackers exhibit the effect, suggesting distinct learning processes for sign and goal tracking.