Author

M. G. Natchus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 5 Organism:rat· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:non-human primate· 1

Frequent Co-Authors

R. Cox· 7 shared R. K. Plemper· 7 shared C. M. Lieber· 5 shared G. R. Painter· 5 shared A. Kolykhalov· 4 shared A. L. Greninger· 4 shared J. Sourimant· 4 shared J.-J. Yoon· 4 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

7 shared papersMicrobiology

R. Cox

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Influenza A virus resistance to 4-fluorouridine coincides with viral attenuation in vitro and in vivo

C. M. Lieber, H.-J. Kang, M. Aggarwal, N. A. P. Lieberman, E. B. Sobolik, J.-J. Yoon, M. G. Natchus, R. Cox, A. L. Greninger, R. K. Plemper

This study identifies mutations conferring resistance to 4-fluorouridine in influenza viruses and shows that resistant variants are attenuated in vivo and can be overcome by higher drug doses.

bioRxiv · Oct 20, 2023 · PreprintMicrobiology

Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets

R. K. Plemper, R. Cox, J. D. Wolf, N. A. P. Lieberman, C. M. Lieber, H.-J. Kang, Z. M. Sticher, J.-J. Yoon, M. K. Andrews, M. Govindarajan, R. E. Krueger, E. B. Sobolik, M. G. Natchus, A. Gewirtz, R. deSwart, , A. L. Greninger

This study shows that prior respiratory virus infections worsen measles severity in ferrets and that antiviral treatment can mitigate immune amnesia and disease outcomes regardless of treatment timing.

bioRxiv · Sep 1, 2023Microbiology

Paxlovid-like nirmatrelvir/ritonavir fails to block SARS-CoV-2 transmission in ferrets

R. Cox, C. M. Lieber, J. D. Wolf, A. Karimi, N. A. P. Lieberman, Z. M. Sticher, P. Roychoudhury, M. K. Andrews, R. E. Krueger, M. G. Natchus, G. R. Painter, A. Kolykhalov, A. L. Greninger, R. K. Plemper

This study compares the efficacy of paxlovid and molnupiravir in preventing SARS-CoV-2 transmission in ferrets, finding that molnupiravir reduces transmission while paxlovid does not.

bioRxiv · Nov 20, 2022 · PreprintMicrobiology

4-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

C. M. Lieber, M. Aggarwal, J.-J. Yoon, R. Cox, J. Sourimant, M. Toots, H.-J. Kang, S. K. Johnson, C. A. Jones, Z. M. Sticher, A. Kolykhalov, M. T. Sindaine, S. M. Tompkins, O. Planz, G. R. Painter, , R. K. Plemper

This study shows 4-Fluorouridine effectively treats seasonal and highly pathogenic influenza viruses in cell culture, organoids, and animal models, preventing lethal infection and transmission.

bioRxiv · Nov 5, 2022 · PreprintMicrobiology

The Prophylactic and Therapeutic Efficacy of the Broadly Active Antiviral Ribonucleoside N4-Hydroxycytidine (EIDD-1931) in a Mouse Model of Lethal Ebola Virus Infection

G. R. Bluemling, S. Mao, M. G. Natchus, W. Painter, S. Mulangu, M. Lockwood, A. D. L. R. De La Rosa, T. Brasel, J. E. Comer, A. N. Freiberg, A. Kolykhalov, G. R. Painter

This study evaluates the efficacy of EIDD-1931, a ribonucleoside analog, in preventing and treating lethal Ebola virus infection in mice.

bioRxiv · Oct 18, 2022 · PreprintMicrobiology

SARS-CoV-2 variant of concern type and biological sex affect efficacy of molnupiravir in dwarf hamster model of severe COVID-19

C. M. Lieber, R. Cox, J. Sourimant, J. D. Wolf, K. Juergens, Q. Phung, M. T. Saindane, M. G. Natchus, G. R. Painter, K. Sakamoto, A. L. Greninger, R. K. Plemper

This study evaluates molnupiravir efficacy against SARS-CoV-2 variants in different models, finding VOC-dependent efficacy and sex-based differences in dwarf hamsters.

bioRxiv · Feb 4, 2022 · PreprintMicrobiology

4'-Fluorouridine is a broad-spectrum orally efficacious antiviral blocking respiratory syncytial virus and SARS-CoV-2 replication

J. Sourimant, C. Lieber, M. Aggarwal, R. Cox, J. Wolf, J.-J. Yoon, M. Toots, C. Ye, Z. Sticher, A. A. Kolykhalov, L. Martinez-Sobrido, G. R. Bluemling, M. G. Natchus, G. R. Painter, R. K. Plemper

This paper identifies 4'-Fluorouridine as an orally effective antiviral that inhibits RSV and SARS-CoV-2 replication in vivo.

bioRxiv · May 19, 2021 · PreprintMicrobiology

Therapeutic Targeting of Measles Virus Polymerase with ERDRP-0519Suppresses All RNA Synthesis Activity

R. Cox, J. Sourimant, M. Govindarajan, M. G. Natchus, R. K. Plemper

This paper characterizes ERDRP-0519, a small molecule inhibitor of measles virus polymerase, showing it blocks all RNA synthesis activity through a unique mechanism.

bioRxiv · Sep 23, 2020Microbiology