Author

C. M. Lieber

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Bioengineering· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:mouse· 8 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Research Focus:clustering· 3 Research Focus:differential expression· 3 Assay:electrophysiology· 3 Organism:human· 3

Frequent Co-Authors

M. G. Natchus· 5 shared R. Cox· 5 shared R. K. Plemper· 5 shared A. L. Greninger· 4 shared A. Kolykhalov· 3 shared A. Zhang· 3 shared G. R. Painter· 3 shared H.-J. Kang· 3 shared

Activity by Year

2022-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersMicrobiology

M. G. Natchus

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Author profile →

10 papers

Recent·Most cited

Influenza A virus resistance to 4-fluorouridine coincides with viral attenuation in vitro and in vivo

C. M. Lieber, H.-J. Kang, M. Aggarwal, N. A. P. Lieberman, E. B. Sobolik, J.-J. Yoon, M. G. Natchus, R. Cox, A. L. Greninger, R. K. Plemper

This study identifies mutations conferring resistance to 4-fluorouridine in influenza viruses and shows that resistant variants are attenuated in vivo and can be overcome by higher drug doses.

bioRxiv · Oct 20, 2023 · PreprintMicrobiology

Biochemically-functionalized probes for cell type-specific targeting and recording in the brain

A. Zhang, T. J. Zwang, C. M. Lieber

This paper develops biochemically-functionalized probes that selectively target and record from specific cell types in the brain, demonstrating their effectiveness in vivo.

bioRxiv · Oct 2, 2023Bioengineering

Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets

R. K. Plemper, R. Cox, J. D. Wolf, N. A. P. Lieberman, C. M. Lieber, H.-J. Kang, Z. M. Sticher, J.-J. Yoon, M. K. Andrews, M. Govindarajan, R. E. Krueger, E. B. Sobolik, M. G. Natchus, A. Gewirtz, R. deSwart, , A. L. Greninger

This study shows that prior respiratory virus infections worsen measles severity in ferrets and that antiviral treatment can mitigate immune amnesia and disease outcomes regardless of treatment timing.

bioRxiv · Sep 1, 2023Microbiology

Injectable ventral spinal stimulator evokes programmable and biomimetic hindlimb motion

D. LIN, J. M. Lee, C. Wang, H.-G. Park, C. M. Lieber

This paper describes an injectable spinal stimulator that enables precise and programmable hindlimb movement in mice by targeting ventral spinal regions.

bioRxiv · Jun 15, 2023Bioengineering

Stitching flexible electronics into the brain

J. M. Lee, D. Lin, Y.-W. Pyo, H.-R. Kim, H.-G. Park, C. M. Lieber

This paper introduces a flexible probe that can be stitched into multiple brain regions of mice to monitor chronic neuronal activity with high stability and minimal immune response.

bioRxiv · Apr 20, 2023Bioengineering

Ultra-flexible endovascular probes for brain recording through micron-scale vasculature

A. Zhang, E. T. Mandeville, L. Xu, C. M. Stary, E. H. Lo, C. M. Lieber

This paper develops ultra-flexible endovascular neural probes for brain recording in small blood vessels without damaging tissue, achieving electrophysiology recordings and long-term stability.

bioRxiv · Mar 20, 2023 · PreprintBioengineering

Paxlovid-like nirmatrelvir/ritonavir fails to block SARS-CoV-2 transmission in ferrets

R. Cox, C. M. Lieber, J. D. Wolf, A. Karimi, N. A. P. Lieberman, Z. M. Sticher, P. Roychoudhury, M. K. Andrews, R. E. Krueger, M. G. Natchus, G. R. Painter, A. Kolykhalov, A. L. Greninger, R. K. Plemper

This study compares the efficacy of paxlovid and molnupiravir in preventing SARS-CoV-2 transmission in ferrets, finding that molnupiravir reduces transmission while paxlovid does not.

bioRxiv · Nov 20, 2022 · PreprintMicrobiology

4-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

C. M. Lieber, M. Aggarwal, J.-J. Yoon, R. Cox, J. Sourimant, M. Toots, H.-J. Kang, S. K. Johnson, C. A. Jones, Z. M. Sticher, A. Kolykhalov, M. T. Sindaine, S. M. Tompkins, O. Planz, G. R. Painter, , R. K. Plemper

This study shows 4-Fluorouridine effectively treats seasonal and highly pathogenic influenza viruses in cell culture, organoids, and animal models, preventing lethal infection and transmission.

bioRxiv · Nov 5, 2022 · PreprintMicrobiology

Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue

T. J. Zwang, R. E. Bennett, M. Lysandrou, B. Woost, A. Zhang, C. M. Lieber, D. S. Richardson, B. T. Hyman

This paper describes a method to rapidly design immunostaining protocols for cleared tissue by using tissue libraries, showing that mouse tissue can substitute for human tissue in protocol optimization.

bioRxiv · May 25, 2022Cell Biology

SARS-CoV-2 variant of concern type and biological sex affect efficacy of molnupiravir in dwarf hamster model of severe COVID-19

C. M. Lieber, R. Cox, J. Sourimant, J. D. Wolf, K. Juergens, Q. Phung, M. T. Saindane, M. G. Natchus, G. R. Painter, K. Sakamoto, A. L. Greninger, R. K. Plemper

This study evaluates molnupiravir efficacy against SARS-CoV-2 variants in different models, finding VOC-dependent efficacy and sex-based differences in dwarf hamsters.

bioRxiv · Feb 4, 2022 · PreprintMicrobiology