Author

J.-J. Yoon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:mouse· 3 Organism:rat· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 1 Organism:non-human primate· 1

Frequent Co-Authors

M. G. Natchus· 4 shared R. Cox· 4 shared R. K. Plemper· 4 shared C. M. Lieber· 3 shared H.-J. Kang· 3 shared M. Aggarwal· 3 shared A. Kolykhalov· 2 shared A. L. Greninger· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersMicrobiology

M. G. Natchus

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Influenza A virus resistance to 4-fluorouridine coincides with viral attenuation in vitro and in vivo

C. M. Lieber, H.-J. Kang, M. Aggarwal, N. A. P. Lieberman, E. B. Sobolik, J.-J. Yoon, M. G. Natchus, R. Cox, A. L. Greninger, R. K. Plemper

This study identifies mutations conferring resistance to 4-fluorouridine in influenza viruses and shows that resistant variants are attenuated in vivo and can be overcome by higher drug doses.

bioRxiv · Oct 20, 2023 · PreprintMicrobiology

Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets

R. K. Plemper, R. Cox, J. D. Wolf, N. A. P. Lieberman, C. M. Lieber, H.-J. Kang, Z. M. Sticher, J.-J. Yoon, M. K. Andrews, M. Govindarajan, R. E. Krueger, E. B. Sobolik, M. G. Natchus, A. Gewirtz, R. deSwart, , A. L. Greninger

This study shows that prior respiratory virus infections worsen measles severity in ferrets and that antiviral treatment can mitigate immune amnesia and disease outcomes regardless of treatment timing.

bioRxiv · Sep 1, 2023Microbiology

4-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

C. M. Lieber, M. Aggarwal, J.-J. Yoon, R. Cox, J. Sourimant, M. Toots, H.-J. Kang, S. K. Johnson, C. A. Jones, Z. M. Sticher, A. Kolykhalov, M. T. Sindaine, S. M. Tompkins, O. Planz, G. R. Painter, , R. K. Plemper

This study shows 4-Fluorouridine effectively treats seasonal and highly pathogenic influenza viruses in cell culture, organoids, and animal models, preventing lethal infection and transmission.

bioRxiv · Nov 5, 2022 · PreprintMicrobiology

4'-Fluorouridine is a broad-spectrum orally efficacious antiviral blocking respiratory syncytial virus and SARS-CoV-2 replication

J. Sourimant, C. Lieber, M. Aggarwal, R. Cox, J. Wolf, J.-J. Yoon, M. Toots, C. Ye, Z. Sticher, A. A. Kolykhalov, L. Martinez-Sobrido, G. R. Bluemling, M. G. Natchus, G. R. Painter, R. K. Plemper

This paper identifies 4'-Fluorouridine as an orally effective antiviral that inhibits RSV and SARS-CoV-2 replication in vivo.

bioRxiv · May 19, 2021 · PreprintMicrobiology