Author

M. Desjardins

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

H. M. McBride· 2 shared J. Lanoix· 2 shared P. Thibault· 2 shared S. Gruenheid· 2 shared A. Ahmadi· 1 shared A. Kazanova· 1 shared A. M. Fahmy· 1 shared A. MacDonald· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersImmunology

H. M. McBride

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Author profile →

5 papers

Recent·Most cited

Comparison of compartmental analytical BOLD fMRI models against Monte Carlo simulations performed over cortical micro-angiograms

J. Charest, M. Walsh, E. Genois, E. Sevigny, P.-O. Schwarz, L. Gagnon, M. Desjardins

The paper compares two BOLD fMRI analytical models against Monte Carlo simulations using mouse cortical micro-angiograms, finding improved accuracy with tridimensional vascular modeling and venous compartment differentiation.

bioRxiv · Mar 6, 2024 · PreprintBiophysics

Modeling gene-environment interactions in Parkinson's Disease: Helicobacter pylori infection of Pink1-/- mice induces CD8 T cell-dependent motor and cognitive dysfunction.

A. Kazanova, J. Sung, N. L. Oliveira, C. Gavino, H. Bessaiah, J. Pei, L. Burns, W. Miller, M. Brouillard-Galipeau, L. Zhu, L. M. Guerra, M. N. Elemeery, S. J. Recinto, A. MacDonald, J. Lanoix, , S. Gruenheid

This study shows that Helicobacter pylori infection in Pink1-/- mice causes motor and cognitive dysfunction linked to CD8 T cell activity, mimicking early PD features.

bioRxiv · Feb 25, 2024 · PreprintImmunology

Parkinson's genes orchestrate pyroptosis through selective trafficking of mtDNA to leaky lysosomes

M. Nguyen, J. J. Collier, O. Ignatenko, G. Morin, S. Huang, M. Desjardins, H. M. McBride

The paper identifies a pyroptotic pathway involving Parkinson's disease proteins and mtDNA trafficking to lysosomes.

bioRxiv · Sep 11, 2023 · PreprintCell Biology

LRRK2 regulates the activation of the unfolded protein response and antigen presentation in macrophages during inflammation

A. M. Fahmy, T. Cannon, C. H. Paredes, A. Ahmadi, Y. Z. Xu, B. Barette, M. Ibrahim, J. Lanoix, G. Arango-Duque, E. Schurr, E. Chevet, P. Thibault, S. Gruenheid, H. McBride, M. Desjardins

This study identifies LRRK2 as a regulator of the unfolded protein response and antigen presentation in macrophages during inflammation, linking it to immune response mechanisms.

bioRxiv · Jun 14, 2023 · PreprintImmunology

Protective heterologous T cell immunity in COVID-19 induced by MMR and Tdap vaccine antigens

T. Mayadas, V. Mysore, X. Cullere, M. L. Settles, M. Kattan, X. Ji, M. Desjardins, B. Durbin-Johnson, T. Gilboa, L. Baden, D. Walt, L. Andrew, L. Jehi

This study shows that prior MMR and Tdap vaccinations generate cross-reactive T cells that reduce severe COVID-19 outcomes.

bioRxiv · May 3, 2021Immunology