Philip J. Santangelo

Wobble Vaccines: Complex Vaccine Antigen Pools Promote Increased Antibody Breadth and Cross-Strain Viral Targeting in SARS-CoV-2

Antigenic characterization of SARS-CoV-2 variants BA.3.2.1 and BA.3.2.2 in three animal models

This study characterizes the antigenic properties of SARS-CoV-2 variants BA.3.2.1 and BA.3.2.2 in three animal models and finds they are antigenically divergent from existing variants with lower homologous serum titers.

CRISP enables comparisons of image-based spatial transcriptomicsegmentation quality across ten organs

The paper benchmarks cell segmentation algorithms for spatial transcriptomics across ten mouse tissues, finding a tradeoff between transcript capture and cell purity, with Proseg performing best overall.

Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells

This study evaluates the effect of transient IL-4 expression from engineered MSCs on M2-like macrophage enrichment after TBI, finding no improvement in functional or histological outcomes.

Synthetic mRNA expressed Cas13a mitigates RNA virus infections

The paper demonstrates that synthetic mRNA expressing Cas13a, guided by crRNA, can target and mitigate RNA virus infections like influenza and hRSV in human cells.