Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids
Yifei Miao, Cheng Peow Bobby Tan, Nicole Min Qian Pek, Zhiyun Yu, Kentaro Iwasawa, Daniel O. Kechele, Nambirajan Sundaram, Victor Pastrana-Gomez, Keishi Kishimoto, Min-Chi Yang, Cheng Jiang, Jason H. Tchieu, Jeffrey A. Whitsett, Kyle W. McCracken, Robbert J. Rottier, , Mingxia Gu
This study develops a human pluripotent stem cell-derived organoid system to investigate vascular, mesenchymal, and epithelial co-development in lung and intestinal organoids, revealing organ-specific endothelial and mesenchymal features.
bioRxiv · Feb 6, 2024 · PreprintDevelopmental Biology