Non-DNA-damaging DNA-PK activation improving hearing and prolonging life due to NAD+ and SIRT upregulation
Yohei Honkura, Takehiro Suzuki, Ryota Kujirai, Shin-ichiro Kanno, Yotaro Matsumoto, Yoshikazu Tanaka, Kowit Hengphasatporn, Satoru Nagatoishi, Alexander Tyshkovskiy, Tomoko Kasahara, Yoshiyasu Tongu, Bohan Zhang, Hitomi Kashiwagi, Chika Saegusa, Msato Fujioka, , Takaaki Abe
This paper shows that MA-5 improves hearing loss and extends lifespan in mice by increasing NAD+ and SIRT1 through DNA-PK activation and mitochondrial function.
bioRxiv · Apr 18, 2025 · PreprintCell Biology