In vivo inhibition of stearoyl-CoA desaturase modulates the hippocampal fatty acid profile and restores density of dendritic spines in the aggressive 5xFAD model of Alzheimer s disease
Marta Turri, Myriam Aubin, Anne Aumont, Annick Vachon, Jessica Avila Lopez, Marian Mayhue, Mélanie Plourde, Karl J. L. Fernandes
This study shows that inhibiting SCD improves fatty acid profiles and restores dendritic spine density in a 5xFAD Alzheimer's model.
bioRxiv · Aug 27, 2025 · PreprintNeuroscience