Author

L. R. Parham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

K. E. Hamilton· 4 shared C. H. Danan· 3 shared K. A. Whelan· 3 shared K. E. Naughton· 3 shared A. Klochkova· 2 shared E. A. McMillan· 2 shared K. Katada· 2 shared L. A. Simon· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersCell Biology

K. E. Hamilton

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4 papers

Recent·Most cited

Autophagy contributes to homeostasis in esophageal epithelium where high autophagic vesicle content marks basal cells with limited proliferation and enhanced self-renewal potential

A. Klochkova, A. L. Karami, A. D. Fuller, L. R. Parham, S. R. Panchani, S. Natarajan, J. L. Jackson, A. Mu, Y. Tan, K. Q. Cai, A. Klein-Szanto, A. B. Muir, M.-P. Tetreault, K. E. Hamilton, K. A. Whelan

The paper investigates autophagy's role in esophageal homeostasis, finding that high autophagic vesicle content in basal cells correlates with limited proliferation and enhanced self-renewal.

bioRxiv · Sep 20, 2023 · PreprintPhysiology

Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival

C. H. Danan, K. E. Naughton, K. E. Hayer, S. Vellapan, E. A. McMillan, Y. Zhou, R. Matsuda, S. K. Nettleford, K. Katada, L. R. Parham, X. Ma, A. Chowdhury, B. J. Wilkins, P. Shah, M. D. Weitzman, K. E. Hamilton

This study shows METTL3 is essential for survival of intestinal transit amplifying cells, maintaining growth factor signaling and KRAS expression, and its deletion leads to intestinal atrophy and death.

bioRxiv · Apr 6, 2023 · PreprintCell Biology

Autophagic state prospectively identifies facultative stem cells in the intestinal epithelium

N. M. Johnson, L. R. Parham, J. Na, K. E. Monaghan, H. M. Kolev, A. Klochkova, M. S. Kim, C. H. Danan, Z. Cramer, L. A. Simon, K. E. Naughton, S. Adams-Tzivelekidis, Y. Tian, P. A. Williams, N. A. Leu, , K. E. Hamilton

The paper identifies autophagic state as a marker for facultative stem cells in the intestinal epithelium, independent of lineage or cell age.

bioRxiv · Apr 8, 2022Cell Biology

IGF2BP1/IMP1 deletion enhances a facultative stem cell state via regulation of MAP1LC3B

L. R. Parham, P. A. Williams, P. Chatterji, K. Acheampong, C. H. Danan, K. Katada, X. Ma, L. A. Simon, K. E. Naughton, R. Mizuno, T. Karakasheva, E. A. McMillan, K. A. Whelan, D. C. Brady, S. M. Shaffer, K. E. Hamilton

The paper shows that deleting IGF2BP1/IMP1 enhances autophagy and tissue regeneration by regulating MAP1LC3B through phosphorylation and cell stress.

bioRxiv · Feb 28, 2022 · PreprintCell Biology