K. E. Hamilton

Lysyl oxidase regulates epithelial differentiation and barrier integrity in eosinophilic esophagitis

This study shows LOX promotes epithelial differentiation and barrier integrity in EoE by activating the BMP pathway through increased BMP2 and reduced follistatin.

Autophagy contributes to homeostasis in esophageal epithelium where high autophagic vesicle content marks basal cells with limited proliferation and enhanced self-renewal potential

The paper investigates autophagy's role in esophageal homeostasis, finding that high autophagic vesicle content in basal cells correlates with limited proliferation and enhanced self-renewal.

Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival

This study shows METTL3 is essential for survival of intestinal transit amplifying cells, maintaining growth factor signaling and KRAS expression, and its deletion leads to intestinal atrophy and death.

Autophagic state prospectively identifies facultative stem cells in the intestinal epithelium

The paper identifies autophagic state as a marker for facultative stem cells in the intestinal epithelium, independent of lineage or cell age.

SLC15A4 favors inflammasome function via mTORC1 signaling and autophagy restraint in dendritic cells

This study identifies SLC15A4 as a regulator of inflammasome function in dendritic cells by linking phagocytosis to mTORC1 signaling and autophagy inhibition.

IGF2BP1/IMP1 deletion enhances a facultative stem cell state via regulation of MAP1LC3B

The paper shows that deleting IGF2BP1/IMP1 enhances autophagy and tissue regeneration by regulating MAP1LC3B through phosphorylation and cell stress.