Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival
C. H. Danan, K. E. Naughton, K. E. Hayer, S. Vellapan, E. A. McMillan, Y. Zhou, R. Matsuda, S. K. Nettleford, K. Katada, L. R. Parham, X. Ma, A. Chowdhury, B. J. Wilkins, P. Shah, M. D. Weitzman, K. E. Hamilton
This study shows METTL3 is essential for survival of intestinal transit amplifying cells, maintaining growth factor signaling and KRAS expression, and its deletion leads to intestinal atrophy and death.
bioRxiv · Apr 6, 2023 · PreprintCell Biology