Author

N. Eckman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

E. Appel· 3 shared B. S. Ou· 2 shared E. L. Meany· 2 shared J. Baillet· 2 shared O. M. Saouaf· 2 shared A. A. A. Auzten· 1 shared A. K. Grosskopf· 1 shared A. K. Swansiger· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersBioengineering

E. Appel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Generation of an inflammatory niche in an injectable hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines

E. L. Meany, J. H. Klich, C. K. Jons, T. Mao, N. Chaudhary, A. Utz, J. Baillet, Y. E. Song, O. M. Saouaf, B. S. Ou, S. C. Williams, N. Eckman, D. J. Irvine, E. Appel

This paper improves mRNA vaccine efficacy by creating an inflammatory immune niche via injectable hydrogel depots that recruit immune cells and enhance humoral responses.

bioRxiv · Jul 5, 2024Bioengineering

Defining Structure-Function Relationships of Amphiphilic Excipients Enables Rational Design of Ultra-Stable Biopharmaceuticals

A. Prossnitz, L. T. Nguyen, N. Eckman, S. Borkar, S. Tetef, A. A. A. Auzten, G. Fuller, E. Appel

The paper designs ultra-stable biopharmaceutical excipients by analyzing structure-function relationships of amphiphilic polymers, significantly improving insulin stability.

bioRxiv · Jun 17, 2024Bioengineering

Label-Free Composition Analysis of Supramolecular Polymer - Nanoparticle Hydrogels by Reversed-Phase Liquid Chromatography Coupled with a Charged Aerosol Detector

S. Tang, Z. Pederson, E. L. Meany, C.-W. Yen, A. K. Swansiger, J. S. Prell, B. Chen, A. K. Grosskopf, N. Eckman, G. Jiang, J. Baillet, J. D. Pellett, E. A. Appel

This paper develops a label-free RPLC-CAD method to analyze supramolecular hydrogel composition and drug payload, demonstrating its applicability for rheological and release kinetic studies.

bioRxiv · Aug 11, 2023Biochemistry

A regimen compression strategy for commercial vaccines leveraging an injectable hydrogel depot technology for sustained vaccine exposure

J. Yan, B. S. Ou, O. M. Saouaf, E. Meany, N. Eckman, E. Appel

This paper develops an injectable hydrogel depot technology for sustained rabies vaccine delivery, showing a single dose can match a standard prime-boost regimen in mice.

bioRxiv · Mar 23, 2023Bioengineering