Author

J. H. Klich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:drug response / drug discovery· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Assay:protein sequence· 1

Frequent Co-Authors

A. K. Grosskopf· 5 shared E. Appel· 4 shared S. Correa· 3 shared A. I. d'Aquino· 2 shared C. K. Jons· 2 shared C. L. Maikawa· 2 shared J. Baillet· 2 shared J. L. Mann· 2 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersBioengineering

A. K. Grosskopf

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5 papers

Recent·Most cited

Stable High-Concentration Monoclonal Antibody Formulations Enabled by an Amphiphilic Copolymer Excipient

J. H. Klich, C. M. Kasse, J. L. Mann, Y. Huang, A. I. d'Aquino, A. K. Grosskopf, J. Baillet, G. G. Fuller, E. Appel

This paper introduces an amphiphilic copolymer excipient that enhances the stability of high-concentration monoclonal antibody formulations without affecting pharmacokinetics or injectability.

bioRxiv · May 25, 2022Bioengineering

Yield Stress and Creep Control Depot Formation and Persistence of Injectable Hydrogels Following Subcutaneous Administration

C. K. Jons, A. K. Grosskopf, J. Baillet, J. Yan, J. H. Klich, E. A. Appel

This study investigates how hydrogel rheological properties affect depot formation and persistence after subcutaneous injection in mice.

bioRxiv · Apr 20, 2022Bioengineering

Delivery of CAR-T Cells in a Transient Injectable Stimulatory Hydrogel Niche Improves Treatment of Solid Tumors

A. K. Grosskopf, L. Labanieh, D. D. Klysz, G. Roth, P. Xu, O. Adebowale, E. C. G. C. Gale, C. K. Jons, J. H. Klich, J. Yan, C. L. Maikawa, S. Correa, B. S. Ou, A. I. d'Aquino, J. R. Cochran, , E. Appel

This paper develops an injectable hydrogel to co-deliver CAR-T cells and cytokines, enhancing solid tumor treatment in mice by creating a transient inflammatory niche.

bioRxiv · Dec 20, 2021Bioengineering

Injectable Liposome Based Supramolecular Hydrogels for the Programmable Release of Multiple Protein Drugs

S. Correa, A. K. Grosskopf, J. H. Klich, H. L. Hernandez, E. Appel

This paper develops injectable liposomal hydrogels that enable the programmed release of multiple protein drugs in vivo.

bioRxiv · Sep 26, 2021Bioengineering

Injectable Nanoparticle-Based Hydrogels Enable the Safe and Effective Deployment of Immunostimulatory CD40 Agonist Antibodies

S. Correa, E. C. Gale, A. T. Mayer, Z. Xiao, C. Liong, J. H. Klich, R. A. Brown, E. L. Meany, O. M. Saouaf, C. L. Maikawa, A. K. Grosskopf, J. L. Mann, J. Idoyaga, E. Appel

This paper develops injectable hydrogels to safely deliver CD40 agonist antibodies, reducing toxicity while maintaining anti-cancer efficacy in a melanoma model.

bioRxiv · Jun 27, 2021Bioengineering