Author

B. S. Ou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 9

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:drug response / drug discovery· 6 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

E. Appel· 8 shared J. Yan· 8 shared O. M. Saouaf· 4 shared A. E. Powell· 3 shared A. K. Grosskopf· 3 shared C. K. Jons· 3 shared E. C. Gale· 3 shared J. Baillet· 3 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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8 shared papersBioengineering

E. Appel

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9 papers

Recent·Most cited

Sustained vaccine exposure elicits more rapid, consistent, and broad humoral immune responses to multivalent influenza vaccines

O. M. Saouaf, B. S. Ou, Y. E. Song, J. J. Carter, J. Yan, C. K. Jons, C. O. Barnes, E. Appel

This study shows sustained delivery of multivalent influenza vaccines via polymer-nanoparticle hydrogels enhances rapid, consistent, and broad humoral immunity against homologous and heterologous strains.

bioRxiv · Apr 28, 2024Bioengineering

Saponin Nanoparticle Adjuvants Incorporating Toll-Like Receptor Agonists Drive Distinct Immune Signatures and Potent Vaccine Responses

B. S. Ou, J. Baillet, M. V. Filsinger Interrante, J. Z. Adamska, X. Zhou, O. Saouaf, J. Yan, J. Klich, C. K. Jons, E. Meany, A. S. Valdez, L. Carter, B. Pulendran, N. P. King, E. Appel

This paper develops a modular saponin-based nanoparticle adjuvant platform incorporating TLR agonists, showing improved vaccine potency and breadth against COVID-19 and HIV in mice.

bioRxiv · Jul 16, 2023 · PreprintBioengineering

A regimen compression strategy for commercial vaccines leveraging an injectable hydrogel depot technology for sustained vaccine exposure

J. Yan, B. S. Ou, O. M. Saouaf, E. Meany, N. Eckman, E. Appel

This paper develops an injectable hydrogel depot technology for sustained rabies vaccine delivery, showing a single dose can match a standard prime-boost regimen in mice.

bioRxiv · Mar 23, 2023Bioengineering

Nanoparticle-Conjugated TLR9 Agonists Improve the Potency, Durability, and Breadth of COVID-19 Vaccines

B. S. Ou, J. Baillet, V. C. T. M. Picece, E. C. Gale, A. E. Powell, O. M. Saouaf, J. Yan, A. Nejatfard, H. Lopez Hernandez, E. Appel

This paper develops CpG nanoparticle adjuvants that enhance the potency, durability, and breadth of COVID-19 vaccines by improving antigen delivery and immune response.

bioRxiv · Jan 2, 2023 · PreprintBioengineering

Broad and Durable Humoral Responses Following Single Hydrogel Immunization of SARS-CoV-2 Subunit Vaccine

B. S. Ou, O. M. Saouaf, J. Yan, T. U. J. Bruun, J. Baillet, X. Zhou, N. P. King, E. Appel

This study develops a single-dose SARS-CoV-2 subunit vaccine using hydrogel technology that generates rapid, broad, and durable humoral immunity compared to traditional multi-dose regimens.

bioRxiv · Dec 12, 2022Bioengineering

Delivery of CAR-T Cells in a Transient Injectable Stimulatory Hydrogel Niche Improves Treatment of Solid Tumors

A. K. Grosskopf, L. Labanieh, D. D. Klysz, G. Roth, P. Xu, O. Adebowale, E. C. G. C. Gale, C. K. Jons, J. H. Klich, J. Yan, C. L. Maikawa, S. Correa, B. S. Ou, A. I. d'Aquino, J. R. Cochran, , E. Appel

This paper develops an injectable hydrogel to co-deliver CAR-T cells and cytokines, enhancing solid tumor treatment in mice by creating a transient inflammatory niche.

bioRxiv · Dec 20, 2021Bioengineering

A cGAMP-containing hydrogel for prolonged SARS-CoV-2 RBD subunit vaccine exposure induces a broad and potent humoral response

V. Böhnert, E. C. Gale, L. J. Lahey, J. Yan, A. E. Powell, B. S. Ou, J. A. Carozza, L. Li, E. Appel

A cGAMP-containing hydrogel vaccine enhances RBD subunit vaccine efficacy by enabling sustained antigen and adjuvant delivery, resulting in broader and more potent antibody responses.

bioRxiv · Jul 3, 2021 · PreprintBioengineering

Engineering Insulin Cold Chain Resilience to Improve Global Access

C. L. Maikawa, J. L. Mann, A. Kannan, C. M. Meis, A. K. Grosskopf, B. S. Ou, A. A. A. Smith, G. G. Fuller, D. M. Maahs, E. A. Appel

This paper develops amphiphilic copolymers to enhance insulin formulation resilience, enabling storage without refrigeration for over 6 months and improving global access to insulin.

bioRxiv · Apr 13, 2021Bioengineering

Hydrogel-based slow release of a receptor-binding domain subunit vaccine elicits neutralizing antibody responses against SARS-CoV-2

E. C. Gale, A. E. Powell, G. A. Roth, E. L. Meany, J. Yan, B. S. Ou, A. K. Grosskopf, J. Adamska, V. C. T. M. Picece, A. I. d'Aquino, B. Pulendran, P. S. Kim, E. Appel

This study shows that slow release of an RBD subunit vaccine via hydrogel enhances neutralizing antibody responses against SARS-CoV-2 compared to bolus administration.

bioRxiv · Mar 31, 2021Bioengineering