E. A. Appel

Label-Free Composition Analysis of Supramolecular Polymer - Nanoparticle Hydrogels by Reversed-Phase Liquid Chromatography Coupled with a Charged Aerosol Detector

This paper develops a label-free RPLC-CAD method to analyze supramolecular hydrogel composition and drug payload, demonstrating its applicability for rheological and release kinetic studies.

Sustained Delivery of GLP-1 Receptor Agonists from Injectable Biomimetic Hydrogels Improves Treatment of Diabetes

This paper develops a hydrogel-based GLP-1 receptor agonist delivery system that provides sustained therapy for up to 42 days in rats, improving diabetes management compared to daily injections.

Polyacrylamide-based Hydrogel Coatings Improve Biocompatibility of Implanted Pump Devices

This study develops polyacrylamide-based hydrogel coatings that improve the biocompatibility of implanted medical devices, extending their functional lifetime in animal models.

Formulation excipients and their role in insulin stability and association state in formulation

This study investigates how excipients affect insulin stability and association state, finding that phenoxyethanol and specific copolymer concentrations enhance monomer content and stability in zinc-free insulin formulations.

Subcutaneous delivery of an antibody against SARS-CoV-2 from a supramolecular hydrogel depot

This paper develops a supramolecular hydrogel depot for subcutaneous delivery of SARS-CoV-2 bnAbs, showing prolonged release and improved pharmacokinetics compared to standard administration.

Yield Stress and Creep Control Depot Formation and Persistence of Injectable Hydrogels Following Subcutaneous Administration

This study investigates how hydrogel rheological properties affect depot formation and persistence after subcutaneous injection in mice.

Real-time monitoring of drug pharmacokinetics within tumor tissue in live animals

This paper develops an implantable sensor to monitor drug pharmacokinetics in tumor tissue in live animals, showing differences from systemic circulation that impact drug efficacy and safety.

Consistent Tumorigenesis with Self-Assembled Hydrogels Enables High-powered Murine Cancer Studies

This paper introduces a hydrogel-based tumor inoculation method that reduces variability in murine tumor growth, enabling more efficient and reliable cancer studies.

Engineering Insulin Cold Chain Resilience to Improve Global Access

This paper develops amphiphilic copolymers to enhance insulin formulation resilience, enabling storage without refrigeration for over 6 months and improving global access to insulin.

Ultra-fast insulin-pramlintide co-formulation for improved glucose management in diabetic rats

This study develops an ultra-fast insulin-pramlintide co-formulation that improves glucose management in diabetic rats by mimicking endogenous co-secretion and reducing patient burden.

Injectable hydrogels for sustained co-delivery of subunit vaccines enhance humoral immunity

This paper introduces an injectable hydrogel platform for sustained co-delivery of subunit vaccines, which enhances humoral immunity by improving antigen and adjuvant presentation over time.

Combinatorial Polyacrylamide Hydrogels for Preventing Biofouling on Implantable Biosensors

This study develops combinatorial polyacrylamide hydrogels that outperform current anti-biofouling coatings in preventing biofouling on biosensors.

Continuous detection of glucose and insulin in live animals

This paper develops a biosensor capable of continuously measuring multiple analytes in live animals with high sensitivity and temporal resolution, demonstrating its use for glucose and insulin detection in diabetic rats.