Author

J. Baillet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 7 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 8 Research Focus:drug response / drug discovery· 5 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:proteomics· 1

Frequent Co-Authors

E. Appel· 5 shared A. K. Grosskopf· 4 shared B. S. Ou· 4 shared J. Yan· 4 shared C. K. Jons· 3 shared E. A. Appel· 3 shared J. H. Klich· 3 shared O. M. Saouaf· 3 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersBioengineering

E. Appel

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Generation of an inflammatory niche in an injectable hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines

E. L. Meany, J. H. Klich, C. K. Jons, T. Mao, N. Chaudhary, A. Utz, J. Baillet, Y. E. Song, O. M. Saouaf, B. S. Ou, S. C. Williams, N. Eckman, D. J. Irvine, E. Appel

This paper improves mRNA vaccine efficacy by creating an inflammatory immune niche via injectable hydrogel depots that recruit immune cells and enhance humoral responses.

bioRxiv · Jul 5, 2024Bioengineering

Label-Free Composition Analysis of Supramolecular Polymer - Nanoparticle Hydrogels by Reversed-Phase Liquid Chromatography Coupled with a Charged Aerosol Detector

S. Tang, Z. Pederson, E. L. Meany, C.-W. Yen, A. K. Swansiger, J. S. Prell, B. Chen, A. K. Grosskopf, N. Eckman, G. Jiang, J. Baillet, J. D. Pellett, E. A. Appel

This paper develops a label-free RPLC-CAD method to analyze supramolecular hydrogel composition and drug payload, demonstrating its applicability for rheological and release kinetic studies.

bioRxiv · Aug 11, 2023Biochemistry

Saponin Nanoparticle Adjuvants Incorporating Toll-Like Receptor Agonists Drive Distinct Immune Signatures and Potent Vaccine Responses

B. S. Ou, J. Baillet, M. V. Filsinger Interrante, J. Z. Adamska, X. Zhou, O. Saouaf, J. Yan, J. Klich, C. K. Jons, E. Meany, A. S. Valdez, L. Carter, B. Pulendran, N. P. King, E. Appel

This paper develops a modular saponin-based nanoparticle adjuvant platform incorporating TLR agonists, showing improved vaccine potency and breadth against COVID-19 and HIV in mice.

bioRxiv · Jul 16, 2023 · PreprintBioengineering

Nanoparticle-Conjugated TLR9 Agonists Improve the Potency, Durability, and Breadth of COVID-19 Vaccines

B. S. Ou, J. Baillet, V. C. T. M. Picece, E. C. Gale, A. E. Powell, O. M. Saouaf, J. Yan, A. Nejatfard, H. Lopez Hernandez, E. Appel

This paper develops CpG nanoparticle adjuvants that enhance the potency, durability, and breadth of COVID-19 vaccines by improving antigen delivery and immune response.

bioRxiv · Jan 2, 2023 · PreprintBioengineering

Broad and Durable Humoral Responses Following Single Hydrogel Immunization of SARS-CoV-2 Subunit Vaccine

B. S. Ou, O. M. Saouaf, J. Yan, T. U. J. Bruun, J. Baillet, X. Zhou, N. P. King, E. Appel

This study develops a single-dose SARS-CoV-2 subunit vaccine using hydrogel technology that generates rapid, broad, and durable humoral immunity compared to traditional multi-dose regimens.

bioRxiv · Dec 12, 2022Bioengineering

Stable High-Concentration Monoclonal Antibody Formulations Enabled by an Amphiphilic Copolymer Excipient

J. H. Klich, C. M. Kasse, J. L. Mann, Y. Huang, A. I. d'Aquino, A. K. Grosskopf, J. Baillet, G. G. Fuller, E. Appel

This paper introduces an amphiphilic copolymer excipient that enhances the stability of high-concentration monoclonal antibody formulations without affecting pharmacokinetics or injectability.

bioRxiv · May 25, 2022Bioengineering

Yield Stress and Creep Control Depot Formation and Persistence of Injectable Hydrogels Following Subcutaneous Administration

C. K. Jons, A. K. Grosskopf, J. Baillet, J. Yan, J. H. Klich, E. A. Appel

This study investigates how hydrogel rheological properties affect depot formation and persistence after subcutaneous injection in mice.

bioRxiv · Apr 20, 2022Bioengineering

Consistent Tumorigenesis with Self-Assembled Hydrogels Enables High-powered Murine Cancer Studies

A. K. Grosskopf, S. Correa, J. Baillet, C. L. Maikawa, E. C. Gale, R. A. Brown, E. A. Appel

This paper introduces a hydrogel-based tumor inoculation method that reduces variability in murine tumor growth, enabling more efficient and reliable cancer studies.

bioRxiv · Apr 13, 2021Bioengineering