R. J. Ju

Tuning non-linear mechanics in collagen hydrogels modulates three dimensional cellular morphotypes

This study shows that altering the non-linear elasticity of collagen hydrogels affects cell morphology, migration, and matrix deformation through mechanical interactions with a second polymer component.

Mechanical confinement induces ferroptosis through mitochondrial dysfunction

This study shows that mechanical confinement triggers ferroptosis via mitochondrial dysfunction by inducing Drp1-dependent fragmentation and cPLA2 translocation.

Persister state-directed transitioning and vulnerability in melanoma

This study identifies a compound that induces a persister state in melanoma cells, promoting differentiation and sensitizing them to a prodrug, offering a dual-target strategy for treatment.

Compression-dependent microtubule reinforcement comprises a mechanostat which enables cells to navigate confined environments

The paper shows that microtubules form a mechanostat to coordinate contractility and nuclear positioning during confined cell migration.

Collagen polarization promotes epithelial elongation by stimulating locoregional cell proliferation.

The paper shows collagen polarization drives epithelial elongation by inducing localized cell proliferation through β1-integrin and ERK signaling.

A Versatile Oblique Plane Microscope for Large-Scale and High-Resolution Imaging of Subcellular Dynamics.

This paper introduces an improved oblique plane microscope with enhanced resolution and usability, demonstrating its application in imaging various subcellular dynamics and challenging biological phenomena.

Caveolae set levels of epithelial monolayer tension to eliminate tumor cells

The paper shows caveolae regulate epithelial tension through lipid signaling, enabling the elimination of oncogene-transformed cells by apical extrusion.