S. Torii

Influence of amino acid substitutions in capsid proteins of coxsackievirus B5 on free chlorine and thermal inactivation

This study investigates how amino acid substitutions in coxsackievirus B5 capsid proteins affect sensitivity to free chlorine and heat, finding that capsid changes have a minor role in chlorine sensitivity but reduce heat sensitivity in specific mutants.

Akaluc bioluminescence offers superior sensitivity to track in vivo dynamics of SARS-CoV-2 infection

This study introduces AkaBLI, a method using Akaluc bioluminescence to track SARS-CoV-2 infection in vivo with higher sensitivity than NanoLuc, showing its utility in monitoring viral dynamics and vaccine efficacy.

The early communication stages between serine proteases and enterovirus capsids in the race for viral disintegration

This study identifies molecular mechanisms by which serine proteases interact with enterovirus capsids, revealing specific residues and structural sites that determine viral inactivation.

Artificial Intelligence Enables the Label-Free Identification of Chronic Myeloid Leukemia Cells with Mitochondrial Morphological Alterations

This study uses AI with flow cytometry to identify CML cells with mitochondrial morphological changes, enabling early diagnosis and monitoring of treatment response.

Zika viruses encode multiple upstream open reading frames in the 5' viral region with a role in neurotropism

This study identifies multiple upstream open reading frames (uORFs) in Zika virus (ZIKV) that influence neurotropism but not mosquito transmission.

Morphogenesis of bullet-shaped rabies virus particles requires a functional interplay between the viral matrix protein and ESCRT-I component TSG101

This study identifies the interaction between rabies virus matrix protein and TSG101 as essential for bullet-shaped virion formation and efficient budding.

Observed Kinetics of Enterovirus Inactivation by Free Chlorine Is Host Cell-Dependent

This study shows that free chlorine inactivates enteroviruses at different rates depending on the host cell used, while UV and heat show consistent inactivation rates across host cells.

Characterization of various remdesivir-resistant mutations of SARS-CoV-2 by mathematical modeling and molecular dynamics simulation.

This study identifies remdesivir-resistant SARS-CoV-2 mutations using viral reconstruction, mathematical modeling, and molecular dynamics simulations, showing mutations reduce antiviral activity without increasing viral production.

An emerging SARS-CoV-2 mutant evading cellular immunity and increasing viral infectivity

This study identifies two SARS-CoV-2 mutations, L452R and Y453F, that evade HLA-restricted cellular immunity and increase viral infectivity.

Versatile live attenuated SARS-CoV-2 vaccine platform applicable to variants induces protective immunity

This study develops a live attenuated SARS-CoV-2 vaccine platform using temperature-sensitive mutations that provides protection against homologous and heterologous viral challenges.

Anti-CoVid19 plasmid DNA vaccine induces a potent immune response in rodents by Pyro-drive Jet Injector intradermal inoculation

This study evaluates a plasmid DNA vaccine against SARS-CoV-2 using a pyro-drive jet injector, showing strong immune response and protection in rodents.

An infectivity-enhancing site on the SARS-CoV-2 spike protein is targeted by COVID-19 patient antibodies

This study identifies an NTD site on SARS-CoV-2 spike protein that enhances infectivity when targeted by antibodies, and finds these antibodies are present in hospitalized patients and some uninfected donors.

The N-terminal domain of spike glycoprotein mediates SARS-CoV-2 infection by associating with L-SIGN and DC-SIGN

This study identifies L-SIGN and DC-SIGN as receptors for the N-terminal domain of SARS-CoV-2 spike protein, showing their role in infection and the importance of anti-NTD antibodies.

Establishment of a reverse genetics system for SARS-CoV-2 using circular polymerase extension reaction

This study develops a PCR-based reverse genetics system for SARS-CoV-2 using CPER to generate infectious clones with high accuracy and titer.