Author

N. P. Keller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 7 Organism:fungi (other)· 3 Organism:zebrafish· 3 Research Focus:database / resource· 2 Assay:metabolomics· 2 Approach:benchmark study· 1 Research Focus:ecology & biodiversity· 1

Frequent Co-Authors

A. Huttenlocher· 3 shared M. T. Drott· 3 shared B. E. Wolfe· 2 shared J. Tannous· 2 shared J. W. Bok· 2 shared N. L. Kelleher· 2 shared T. J. Schoen· 2 shared A. Lind· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersMicrobiology

A. Huttenlocher

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Terpenoid balance in Aspergillus nidulans unveiled by heterologous squalene synthase expression

S. C. Park, B. N. Steffan, F. Y. Lim, R. Gupta, F. A. Butun, H. Chen, R. Ye, T. Decker, C. C. Wu, N. L. Kelleher, J. W. Bok, N. P. Keller

The paper shows that expressing a heterologous squalene synthase from Pseudogymnoascus destructans in Aspergillus nidulans alters terpene biosynthesis, increasing squalene and new nidulenes while reducing austinol.

bioRxiv · Oct 20, 2023 · PreprintMicrobiology

Mining for a New Class of Fungal Natural Products: The Evolution, Diversity, and Distribution of Isocyanide Synthase Biosynthetic Gene Clusters

G. R. Nickles, B. Oestereicher, N. P. Keller, M. T. Drott

The paper identifies 3,800 isocyanide synthase biosynthetic gene clusters across 3,300 fungal genomes, revealing their evolutionary history and distribution, and develops a resource for their exploration.

bioRxiv · Apr 17, 2023Microbiology

Aspergillus fumigatus transcription factor ZfpA regulates hyphal development and alters susceptibility to antifungals and neutrophil killing during infection

N. P. Keller, T. J. Schoen, D. G. Calise, J. W. Bok, C. D. Nwagwu, R. Zarnowski, D. Andes, A. Huttenlocher

bioRxiv · Jan 25, 2023 · PreprintMicrobiology

Fungal antibiotics control bacterial community diversity in the cheese rind microbiome

J. Tannous, C. Cosetta, M. T. Drott, T. A. Rush, P. E. Abraham, R. J. Giannone, N. P. Keller, B. E. Wolfe

This study shows that fungal antibiotics, specifically pseurotins, regulate bacterial community diversity in cheese rind microbiomes by controlling bacterial abundance and composition.

bioRxiv · Nov 26, 2022 · PreprintMicrobiology

Cyclooxygenase production of PGE2 promotes phagocyte control of A. fumigatus hyphal growth in larval zebrafish

S. Thrikawala, M. Niu, N. P. Keller, E. Rosowski

This study identifies COX signaling via the PGE2-EP2 pathway as critical for phagocyte control of A. fumigatus hyphal growth in zebrafish larvae.

bioRxiv · Oct 19, 2021Immunology

An Interpreted Atlas of Biosynthetic Gene Clusters from 1000 Fungal Genomes

M. T. Robey, L. K. Caesar, M. T. Drott, N. P. Keller, N. L. Kelleher

The paper systematically analyzes biosynthetic gene clusters from 1000 fungal genomes to create an interpreted atlas of fungal natural products and their chemical space.

bioRxiv · Sep 21, 2020Biochemistry

From iron to antibiotics: Identification of conserved bacterial-fungal interactions across diverse partners

E. C. Pierce, M. Morin, J. C. Little, R. B. Liu, J. Tannous, N. P. Keller, B. E. Wolfe, K. Pogliano, L. M. Sanchez, R. J. Dutton

This study identifies conserved bacterial-fungal interactions across 16 bacterial-fungal pairs, revealing that fungi modulate iron and biotin availability and produce uncharacterized antibiotics.

bioRxiv · Mar 19, 2020Microbiology

Functional characterization of clinical isolates of the opportunistic fungal pathogen Aspergillus nidulans

R. W. Bastos, C. Valero, L. P. Silva, T. Schoen, M. Drott, V. Brauer, R. Silva-Rocha, A. Lind, J. L. Steenwyk, A. Rokas, F. Rodrigues, A. Resendiz-Sharpe, K. Lagrou, M. Marcet-Houben, T. Gabaldon, , G. H. Goldman

This study characterizes two clinical isolates of A. nidulans, showing differences in growth, metabolism, stress response, and virulence compared to a reference strain.

bioRxiv · Jan 28, 2020Microbiology

Imaging invasive fungal growth and inflammation in NADPH oxidase-deficient zebrafish

A. Huttenlocher, T. J. Schoen, E. E. Rosowski, B. P. Knox, D. Bennin, N. P. Keller

The paper uses zebrafish to study how neutrophil ROS affects fungal growth and inflammation during infection with Aspergillus nidulans, finding that ROS limits fungal growth and reduces inflammation in PHOX-deficient hosts.

bioRxiv · Jul 16, 2019 · PreprintCell Biology