Author

C. C. Wu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:benchmarking· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:database / resource· 1

Frequent Co-Authors

M. J. MacCoss· 4 shared D. L. Plubell· 3 shared M. Riffle· 3 shared A. N. Hoofnagle· 2 shared B. X. MacLean· 2 shared E. Huang· 2 shared G. E. Merrihew· 2 shared J. Park· 2 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersBiochemistry

M. J. MacCoss

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Author profile →

6 papers

Recent·Most cited

A framework for quality control in quantitative proteomics

K. A. Tsantilas, G. E. Merrihew, J. E. Robbins, R. S. Johnson, J. Park, D. L. Plubell, J. D. Canterbury, E. Huang, M. Riffle, V. Sharma, B. X. MacLean, J. Eckels, C. C. Wu, M. S. Bereman, S. E. Spencer, , M. J. MacCoss

The paper introduces a framework for quality control in quantitative proteomics, combining internal and external QC measures with tools for data analysis and deposition.

bioRxiv · Apr 12, 2024Biochemistry

Turnover of PPP1R15A mRNA encoding GADD34 controls the molecular memory of the cellular integrated stress response

V. Magg, A. Manetto, K. Kopp, C. C. Wu, M. Naghizadeh, D. Lindner, L. Eke, J. Welsch, S. M. Kallenberger, J. Schott, V. Haucke, N. Locker, G. Stoecklin, A. Ruggieri

The paper identifies a mechanism by which PPP1R15A mRNA stability regulates GADD34 expression, controlling the cellular integrated stress response's memory and adaptation to stress.

bioRxiv · Nov 11, 2023 · PreprintCell Biology

Terpenoid balance in Aspergillus nidulans unveiled by heterologous squalene synthase expression

S. C. Park, B. N. Steffan, F. Y. Lim, R. Gupta, F. A. Butun, H. Chen, R. Ye, T. Decker, C. C. Wu, N. L. Kelleher, J. W. Bok, N. P. Keller

The paper shows that expressing a heterologous squalene synthase from Pseudogymnoascus destructans in Aspergillus nidulans alters terpene biosynthesis, increasing squalene and new nidulenes while reducing austinol.

bioRxiv · Oct 20, 2023 · PreprintMicrobiology

Mag-Net: Rapid enrichment of membrane-bound particles enables high coverage quantitative analysis of the plasma proteome

C. C. Wu, K. A. Tsantilas, J. Park, D. L. Plubell, J. A. Sanders, P. Naicker, I. Govender, S. Buthelezi, S. Stoychev, J. Jordaan, G. E. Merrihew, E. Huang, E. D. Parker, M. Riffle, A. N. Hoofnagle, , M. J. MacCoss

Mag-Net enriches membrane-bound particles from plasma to identify disease-specific proteins, discovering 204 proteins differentiating Alzheimer's disease dementia from controls.

bioRxiv · Jun 10, 2023 · PreprintBiochemistry

Evaluating the performance of the Astral mass analyzer for quantitative proteomics using data independent acquisition

L. R. Heil, N. E. Damoc, T. N. Arrey, A. Pashkova, E. Denisov, J. Petzoldt, A. Peterson, C. Hsu, B. C. Searle, N. Shulman, M. Riffle, B. Connolly, B. X. MacLean, P. M. Remes, M. Senko, , M. J. MacCoss

The paper evaluates the Astral mass analyzer's performance in quantitative proteomics, showing it quantifies 5 times more peptides per unit time than existing Orbitrap mass spectrometers and detects over 5,000 plasma proteins.

bioRxiv · Jun 3, 2023 · PreprintBiochemistry

Can we put Humpty Dumpty back together again? What does protein quantification mean in bottom-up proteomics?

D. L. Plubell, L. Käll, B.-J. Webb-Robertson, L. Bramer, A. Ives, N. L. Kelleher, L. M. Smith, T. J. Montine, C. C. Wu, M. J. MacCoss

The paper questions the assumption that all peptides from a protein coding gene represent the same protein quantity in bottom-up proteomics, highlighting the need for better methods to account for proteomic complexity.

bioRxiv · Jan 25, 2021 · PreprintBiochemistry