Author

M. Niu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 2 Animal Behavior & Cognition· 1 Biophysics· 1 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 4 Approach:statistical model· 4 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

H. Wang· 2 shared Z. Su· 2 shared A. E. Barry· 1 shared A. J. Nelson· 1 shared A. J. Trease· 1 shared A. L. Frazier· 1 shared A. Monette· 1 shared A. Mouland· 1 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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2 shared papersPathology

H. Wang

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11 papers

Recent·Most cited

Microglia and macrophages alterations in the CNS during acute SIV infection: a single-cell analysis in rhesus macaques

X. Xu, M. Niu, B. G. Lamberty, K. Emanuel, A. J. Trease, M. Tabassum, J. D. Lifson, H. S. Fox

This study uses single-cell RNA sequencing to analyze microglia and macrophages in rhesus macaques during acute SIV infection, revealing changes in cell clusters and gene expression linked to inflammation and neurodegeneration.

bioRxiv · Apr 4, 2024Microbiology

Late-Life Alcohol Exposure Does Not Exacerbate Age-Dependent Reductions in Mouse Spatial Memory and Brain TFEB Activity

H. Chen, K. Hinz, C. Zhang, Y. Rodriguez, S. N. Williams, M. Niu, X. Ma, X. Chao, A. L. Frazier, K. E. McCarson, X. Wang, Z. Peng, W. Liu, H.-M. Ni, J. Zhang, , W.-X. Ding

This study examines the effects of late-life alcohol exposure on spatial memory and TFEB activity in young and aged mice, finding that aging has a greater impact than alcohol.

bioRxiv · Feb 23, 2024Animal Behavior & Cognition

Step-wise mechanical unfolding and dissociation of the GAIN domains of ADGRG1/GPR56, ADGRL1/Latrophilin-1 and ADGRB3/BAI3: insights into the mechanical activation hypothesis of adhesion G protein-coupled receptors

C. Fu, W. Huang, Q. Tang, M. Niu, S. Guo, T. Langenhan, G. Song, J. Yan

This study examines how mechanical forces affect the GAIN domains of three aGPCRs, showing force-induced destabilization and detachment, supporting the mechanical activation hypothesis.

bioRxiv · Mar 14, 2023 · PreprintBiophysics

Influence of HIV-1 genomic RNA on the formation of Gagbiomolecular condensates

A. Monette, M. Niu, R. K. Maldonado, J. Chang, G. S. Lambert, J. M. Flanagan, A. W. Cochrane, L. J. Parent, A. Mouland

This study investigates how HIV-1 genomic RNA influences Gag biomolecular condensate formation and size, revealing salt-dependent effects of mutations and compartment-specific differences in host factors.

bioRxiv · Feb 23, 2023Microbiology

Taxonomic and carbon metabolic diversification of Bathyarchaeia during its co-evolution history with the early Earth surface environment

J. Hou, Y. Wang, P. Zhu, N. Yang, L. Liang, T. Yu, M. Niu, K. Konhauser, F. Wang

This study investigates the evolutionary history and metabolic diversity of Bathyarchaeia, linking their diversification to geological events and environmental changes.

bioRxiv · Nov 19, 2022 · PreprintMicrobiology

Cyclooxygenase production of PGE2 promotes phagocyte control of A. fumigatus hyphal growth in larval zebrafish

S. Thrikawala, M. Niu, N. P. Keller, E. Rosowski

This study identifies COX signaling via the PGE2-EP2 pathway as critical for phagocyte control of A. fumigatus hyphal growth in zebrafish larvae.

bioRxiv · Oct 19, 2021Immunology

Prevalent uses and evolution of exonic regulatory sequences in the human genome

J. Chen, P. Ni, M. Niu, J.-t. Guo, Z. Su

The paper investigates the prevalence and evolution of exonic regulatory sequences, finding that exonic TFBSs are common and may evolve into regulatory elements when non-exonic sequences are unavailable.

bioRxiv · Sep 6, 2021Evolutionary Biology

Gradients of receptor expression in the macaque cortex

S. Froudist-Walsh, T. Xu, M. Niu, L. Rapan, K. Zilles, D. S. Margulies, X.-J. Wang, N. Palomero-Gallagher

The paper maps receptor expression gradients in macaque cortex, revealing a hierarchy aligned with cortical function and a depression-related gradient in specific regions.

bioRxiv · Feb 22, 2021 · PreprintNeuroscience

Inhibition of HSP90 reversed STAT3 mediated muscle wasting induced by cancer cachexia

H. Wang, M. Niu, S. Song, Z. Su, L. Wei, L. Li, W. Pu, C. Zhao, Y. Ding, W. Cao, Q. Gao

The paper shows that inhibiting HSP90 reduces STAT3-mediated muscle wasting in cancer cachexia by disrupting the HSP90/STAT3/FOXO1 axis.

bioRxiv · Jan 27, 2021 · PreprintPathology

The bone microenvironment invigorates metastatic seeds for further dissemination

W. Zhang, I. L. Bado, H. Wang, S. Singh, H.-C. Lo, M. Niu, Z. Xu, J. Liu, W. Jiang, Y. Li, J. Hu, X. H. - F. Zhang

This study shows the bone microenvironment enhances metastatic potential of cancer cells, enabling further dissemination and multi-organ metastasis, independent of genetic selection.

bioRxiv · Nov 16, 2020Cancer Biology

High-Throughput Analysis of Lung Immune Cells in a Murine Model of Rheumatoid Arthritis-Associated Lung Disease

R. Gaurav, T. R. Mikuls, G. M. Thiele, A. J. Nelson, M. Niu, C. Guda, J. D. Eudy, A. E. Barry, T. A. Wyatt, D. J. Romberger, M. J. Duryee, B. R. England, J. A. Poole

The paper analyzes lung immune cell populations in a murine RA model using single-cell RNA-seq and NanoString to identify gene expression patterns linked to RA-associated lung disease.

bioRxiv · Oct 2, 2020Immunology