N. S. Heaton

Influenza virus transcription and progeny production are poorly correlated in single cells

This study measures both viral transcription and progeny production in single influenza-infected cells, finding they are poorly correlated.

Influenza viral particles harboring the SARS-CoV-2 spike RBD as a combination respiratory disease vaccine

This paper develops a combination vaccine using recombinant influenza A virus to deliver SARS-CoV-2 spike RBD, showing protection against both pathogens.

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro

The paper screens 1,900 drugs to find inhibitors of SARS-CoV-2 replication, identifies masitinib as a 3CLpro inhibitor effective in vitro, and shows its broad anti-viral activity.

ETV7 limits antiviral gene expression and control of SARS-CoV-2 and influenza viruses

This study identifies ETV7 as a negative regulator of antiviral interferon-stimulated genes important for controlling influenza and SARS-CoV-2 infections.

Development of a fluorescence based, high-throughput SARS-CoV-2 3CLpro reporter assay

This paper develops a fluorescence-based, high-throughput assay to screen for SARS-CoV-2 3CLpro inhibitors using a GFP-derived reporter that fluoresces after protease cleavage.

Replication competent, 10-segmented influenza viruses as antiviral therapeutics

This paper develops 10-segmented influenza viruses that act as antiviral therapeutics by interfering with viral assembly and reducing infectious spread.