Author

Nicholas A. Saba

University of North Carolina at Chapel Hill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

Che-Kang ChangiD· 2 shared John D. SearsiD· 2 shared Mark T. HeiseiD· 2 shared Nathaniel J. MoormaniD· 2 shared Wes SandersiD· 2 shared Adam M. DrobishiD· 1 shared Amanda J. GrammiD· 1 shared Bose Muthu Ramalingam· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Che-Kang ChangORCID

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2 papers

Recent·Most cited

Functional Roles for RNA Ribosylation in Mammalian Cells

John D. Sears, Che-Kang Chang, Takayoshi Shirasaki, Rebekah J. Dickmander, Nicholas A. Saba, Wes Sanders, Mark T. Heise, Nathaniel J. Moorman

This study shows RNA ribosylation inhibits translation, decreases RNA stability, and activates antiviral immune responses in mammalian cells during chikungunya virus infection.

bioRxiv · Jul 18, 2025 · PreprintCell Biology

Identification of a Broadly Acting Inhibitor of the Alphavirus Non-Structural Protein 2 Helicase

John D. Sears, Durbadal Ojha, Sharon Taft-Benz, Paul Sylvester, Zachary J. Streblow, Amanda J. Gramm, Adam M. Drobish, Bose Muthu Ramalingam, Mohammad Anwar Hossain, Kacey Marie Talbot, Wes Sanders, Che-Kang Chang, Isabella Law, Sabian A. Martinez, Jane Burdick, , Nathaniel J. Moorman

This study identifies a first-in-class inhibitor of alphavirus nsP2 helicase activity, showing broad antiviral activity and in vivo efficacy against chikungunya virus.

bioRxiv · Jun 3, 2025 · PreprintMicrobiology