Author

Che-Kang Chang

University of North Carolina at Chapel HillORCID 0000-0002-5347-773XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

John D. SearsiD· 3 shared Mark T. HeiseiD· 3 shared Nathaniel J. MoormaniD· 3 shared Wes SandersiD· 3 shared Adam M. DrobishiD· 2 shared Craig E. CameroniD· 2 shared Jamie J. ArnoldiD· 2 shared Nicholas A. Saba· 2 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

John D. SearsORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Novel Computational Pipeline to Identify Target Sites for Broad Spectrum Antiviral Drugs

John D. Sears, Konstantin Popov, Dr Paul Sylvester, Rebekah J. Dickmander, Jennifer Loome-Diaz, Che-Kang Chang, Julia Huff, Wes Sanders, Noore Saba, Madeleine R. Sorensen, Adam M. Drobish, Nicholas A. May, Kevin E. W. Namitz, Julia Ann Fecko, Jamie J. Arnold, , Nathaniel J. Moorman

This paper develops a computational pipeline to identify conserved antiviral target sites in alphaviruses using AI-driven methods, validating potential drug targets through mutagenesis.

Antiviral Research · Dec 1, 2025Peer-reviewedMicrobiology

Functional Roles for RNA Ribosylation in Mammalian Cells

John D. Sears, Che-Kang Chang, Takayoshi Shirasaki, Rebekah J. Dickmander, Nicholas A. Saba, Wes Sanders, Mark T. Heise, Nathaniel J. Moorman

This study shows RNA ribosylation inhibits translation, decreases RNA stability, and activates antiviral immune responses in mammalian cells during chikungunya virus infection.

bioRxiv · Jul 18, 2025 · PreprintCell Biology

Identification of a Broadly Acting Inhibitor of the Alphavirus Non-Structural Protein 2 Helicase

John D. Sears, Durbadal Ojha, Sharon Taft-Benz, Paul Sylvester, Zachary J. Streblow, Amanda J. Gramm, Adam M. Drobish, Bose Muthu Ramalingam, Mohammad Anwar Hossain, Kacey Marie Talbot, Wes Sanders, Che-Kang Chang, Isabella Law, Sabian A. Martinez, Jane Burdick, , Nathaniel J. Moorman

This study identifies a first-in-class inhibitor of alphavirus nsP2 helicase activity, showing broad antiviral activity and in vivo efficacy against chikungunya virus.

bioRxiv · Jun 3, 2025 · PreprintMicrobiology

Che-Kang Chang · henhao