Author

Sabian A. Martinez

University of North Carolina at Chapel HillORCID 0000-0002-1333-5083Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Daniel N. StreblowiD· 3 shared Isabella LawiD· 3 shared Jane BurdickiD· 3 shared John D. SearsiD· 3 shared Mark T. HeiseiD· 3 shared Mohammad Anwar HossainiD· 3 shared Nathaniel J. MoormaniD· 3 shared Rafael M. CouñagoiD· 3 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersPharmacology & Toxicology

Daniel N. StreblowORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

N-Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad Spectrum Antialphaviral Activity

Anirban Ghoshal, John D. Sears, Mohammad Anwar Hossain, Edwin G. Tse, Stefanie Howell, Jane Burdick, Noah L. Morales, Sabian A. Martinez, Isabella Law, Zachary J. Streblow, Daniel N. Streblow, Rafael M. Couñago, Nathaniel J. Moorman, Mark T. Heise, Timothy Mark Willson

Journal of Medicinal Chemistry · Oct 15, 2025Peer-reviewedPharmacology & Toxicology

Identification of a Broadly Acting Inhibitor of the Alphavirus Non-Structural Protein 2 Helicase

John D. Sears, Durbadal Ojha, Sharon Taft-Benz, Paul Sylvester, Zachary J. Streblow, Amanda J. Gramm, Adam M. Drobish, Bose Muthu Ramalingam, Mohammad Anwar Hossain, Kacey Marie Talbot, Wes Sanders, Che-Kang Chang, Isabella Law, Sabian A. Martinez, Jane Burdick, , Nathaniel J. Moorman

This study identifies a first-in-class inhibitor of alphavirus nsP2 helicase activity, showing broad antiviral activity and in vivo efficacy against chikungunya virus.

bioRxiv · Jun 3, 2025 · PreprintMicrobiology

Identification of Direct-acting nsP2 Helicase Inhibitors with Anti-alphaviral Activity

M. Bose, John D. Sears, Kacey Marie Talbot, Yuan-Wei Norman Su, Scott Houliston, Mohammad Anwar Hossain, Zachary W. Davis‐Gilbert, Chunqing Zhao, Hans J. Oh, Peter J. Brown, Marcia K. Sanders, Stella R. Moorman, Durbadal Ojha, Jane Burdick, Isabella Law, , Timothy Mark Willson

This paper identifies and optimizes oxaspiropiperidine inhibitors targeting nsP2hel, showing nanomolar antiviral activity against multiple alphaviruses.

bioRxiv · Mar 4, 2025 · PreprintPharmacology & Toxicology