O. Stepanek

ABIN1 is a negative regulator of effector functions in cytotoxic T cells

This study identifies ABIN1 as a negative regulator of effector functions in cytotoxic T cells, showing its role in suppressing NF-κB and p38 pathways.

BBSome-deficient cells activate intraciliary CDC42 to trigger actin-dependent ciliary ectocytosis

This study identifies CDC42 as a key trigger of ciliary ectocytosis in BBSome-deficient cells, leading to cilia shortening and loss of ciliary material.

Matters Arising: FBXO38 does not control PD-1 stability

This study investigates whether FBXO38 regulates PD-1 stability in T cells and finds no evidence supporting this claim.

Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2

This study identifies Tregs suppressing KLRK1+ IL7R+ CD8+ effector T cells by limiting IL-2, which enhances autoimmunity and anti-tumor responses.

Phenotypic and clonal stability of antigen-inexperienced memory-like T cells across the genetic background, hygienic status, and aging

This study characterizes antigen-inexperienced memory-like T cells across genetic backgrounds, hygienic conditions, and aging, showing their clonal stability and distinct subsets defined by CD122 expression.

The BBSome assembly is spatially controlled by BBS1 and BBS4 in human cells

The paper investigates BBSome assembly in human cells, showing that BBS4 nucleates pre-BBSome at pericentriolar satellites and BBS1 mediates its translocation to the ciliary base.

Strong homeostatic TCR signals induce formation of self-tolerant virtual memory CD8 T cells

The paper shows that virtual memory CD8 T cells arise from strongly self-reactive T cells and are regulated by CD8-Lck stoichiometry, but do not exhibit increased autoimmune potential.