Author

A. Drobek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Assay:CITE-seq· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

O. Stepanek· 4 shared J. Michalik· 3 shared A. Moudra· 2 shared A. Neuwirth· 2 shared J. Prochazka· 2 shared M. Pribikova· 2 shared P. Draber· 2 shared R. Sedlacek· 2 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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4 shared papersImmunology

O. Stepanek

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5 papers

Recent·Most cited

ABIN1 is a negative regulator of effector functions in cytotoxic T cells

S. Janusova, D. Paprckova, J. Michalik, V. Uleri, A. Drobek, E. Salyova, L. Chorfi, A. Neuwirth, J. Prochazka, R. Sedlacek, P. Draber, O. Stepanek

This study identifies ABIN1 as a negative regulator of effector functions in cytotoxic T cells, showing its role in suppressing NF-κB and p38 pathways.

bioRxiv · Oct 25, 2023Immunology

Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2

O. Tsyklauri, T. Chadimova, V. Niederlova, J. Kovarova, J. Michalik, I. Malatova, S. Janusova, O. Ivashchenko, H. Rossez, A. Drobek, H. Vecerova, V. Galati, M. Kovar, O. Stepanek

This study identifies Tregs suppressing KLRK1+ IL7R+ CD8+ effector T cells by limiting IL-2, which enhances autoimmunity and anti-tumor responses.

bioRxiv · Nov 10, 2021Immunology

Phenotypic and clonal stability of antigen-inexperienced memory-like T cells across the genetic background, hygienic status, and aging

A. Moudra, V. Niederlova, J. Novotny, L. Schmiedova, J. Kubovciak, T. Matejkova, A. Drobek, M. Pribikova, R. Stopkova, D. Cizkova, A. Neuwirth, J. Michalik, K. Krizova, T. Hudcovic, M. Kolar, , O. Stepanek

This study characterizes antigen-inexperienced memory-like T cells across genetic backgrounds, hygienic conditions, and aging, showing their clonal stability and distinct subsets defined by CD122 expression.

bioRxiv · Sep 1, 2020Immunology

Regulation of neutrophil NADPH oxidase by PSTPIP2 affects bone damage in murine autoinflammatory osteomyelitis

J. Kralova, A. Drobek, J. Prochazka, F. Spoutil, D. Glatzova, S. Borna, J. Pokorna, T. Skopcova, P. Angelisova, M. Gregor, P. Kovarik, R. Sedlacek, T. Brdicka

This study shows that PSTPIP2 regulates neutrophil NADPH oxidase, and its loss leads to increased ROS production and bone damage in a murine model of autoinflammatory osteomyelitis.

bioRxiv · Aug 6, 2019 · PreprintImmunology

Strong homeostatic TCR signals induce formation of self-tolerant virtual memory CD8 T cells

A. Drobek, A. Moudra, D. Mueller, M. Huranova, V. Horkova, M. Pribikova, R. Ivanek, S. Oberle, D. Zehn, K. D. McCoy, P. Draber, O. Stepanek

The paper shows that virtual memory CD8 T cells arise from strongly self-reactive T cells and are regulated by CD8-Lck stoichiometry, but do not exhibit increased autoimmune potential.

bioRxiv · Oct 13, 2017Immunology