V. S. W. Li

Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target

This study uses metabolomics to stratify colorectal cancer tissues and identifies adenosylhomocysteinase as a potential therapeutic target.

USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development

This study shows that USP7 inactivation suppresses intestinal tumor development in APC-mutant mice but causes colitis with prolonged deletion and is effective against patient-derived cancer organoids.

SARS-CoV-2 infection and replication in human fetal and pediatric gastric organoids

This paper shows that SARS-CoV-2 can infect and replicate in pediatric gastric organoids but not in fetal ones, suggesting differential susceptibility based on developmental stage.

Identifying strategies to target the metabolic flexibility of tumours.

The paper identifies compensatory metabolic mechanisms in tumours and shows that targeting these can improve therapeutic outcomes.

Engineering transplantable jejunal mucosal grafts using primary patient-derived organoids from children with intestinal failure

This study develops a method to create transplantable jejunal mucosal grafts using patient-derived organoids and decellularized scaffolds, demonstrating functional grafts in vitro and in vivo.

Single-Cell Signalling Analysis of Heterocellular Organoids

This study uses mass cytometry to analyze cell-type specific signaling networks in organoids and reveals how genetic mutations mimic stromal cell signaling in cancer organoids.