Author

D. J. Rigden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Biophysics· 1 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. J. Simpkin· 2 shared A. Bowers-Barnard· 1 shared A. P. Jackson· 1 shared C. L. Dulberger· 1 shared C. Sun· 1 shared C. V. Pulford· 1 shared D. A. Rasko· 1 shared D. G. Fernig· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBiophysics

A. J. Simpkin

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Author profile →

5 papers

Recent·Most cited

Assessment of three-dimensional RNA structure prediction in CASP15

R. Das, R. C. Kretsch, A. J. Simpkin, T. Mulvaney, P. Pham, R. Rangan, F. Bu, R. M. Keegan, M. Topf, D. J. Rigden, Z. Miao, E. Westhof

This paper evaluates RNA 3D structure prediction methods in CASP15, finding that non-deep learning groups outperformed deep learning models, with challenges in fine details and model ranking.

bioRxiv · Apr 25, 2023Biophysics

Informing shigellosis prevention and control through pathogen genomics

R. J. Bengtsson, A. J. Simpkin, C. V. Pulford, R. Low, D. A. Rasko, D. J. Rigden, N. Hall, E. M. Barry, S. M. Tennant, K. S. Baker

This study uses genomic analysis of Shigella strains from seven LMIC to show S. sonnei's high disease contribution and convergent antimicrobial resistance evolution, highlighting the need for updated vaccine and treatment strategies.

bioRxiv · Jun 9, 2021 · PreprintMicrobiology

The Paracaedibacter-like endosymbiont of Bodo saltans (Kinetoplastida) uses multiple putative toxin-antitoxin systems to maintain its host association

S. Midha, D. J. Rigden, S. Siozios, G. D. D. Hurst, A. P. Jackson

This study identifies a Paracaedibacter-like endosymbiont in Bodo saltans that uses toxin-antitoxin systems to maintain host association, leading to cell death when the endosymbiont is removed.

bioRxiv · Jul 24, 2020Ecology

Prophage-encoded phage defence proteins with cognate self-immunity

S. V. Owen, N. Wenner, C. L. Dulberger, E. V. Rodwell, A. Bowers-Barnard, N. Quinones-Olvera, D. J. Rigden, E. J. Rubin, E. C. Garner, M. Baym, J. C. D. Hinton

The paper identifies BstA, a prophage-encoded phage defense protein that suppresses phage epidemics through abortive infection, with self-immunity mediated by the anti-BstA element.

bioRxiv · Jul 13, 2020Microbiology

The heparin-binding proteome in normal pancreas and murine experimental acute pancreatitis

Q. M. Nunes, D. Su, P. J. Brownridge, D. M. Simpson, C. Sun, y. li, P. T. P. Bui, X. Zhang, W. Huang, D. J. Rigden, R. J. Beynon, R. Sutton, D. G. Fernig

This study identifies extracellular heparin-binding proteins (HBPs) in normal and acute pancreatitis mouse pancreas and plasma, revealing their roles in homeostasis and inflammation.

PLOS ONE · Jun 18, 2019Peer-reviewedBiochemistry