Author

P. Ligoxygakis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 7 Organism:Drosophila· 6 Research Focus:cell type annotation· 4 Research Focus:gene regulatory network inference· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Organism:C. elegans· 2

Frequent Co-Authors

M. A. Sloan· 3 shared J. A. Cotton· 2 shared L. Wang· 2 shared A. Damianou· 1 shared A. Pielach· 1 shared A. Pinto-Fernandez· 1 shared B. M. Kessler· 1 shared E. Johnson· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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3 shared papersMicrobiology

M. A. Sloan

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Analysis of the influence of peptidoglycan turnover and recycling on host-pathogen interaction in the Gram-positive pathogen Staphylococcus aureus

J. Dorling, M. D. Atilano, E. Pires, E. Johnson, A. Pielach, J. McCullagh, S. R. Filipe, P. Ligoxygakis

This study investigates the role of peptidoglycan turnover and recycling in S. aureus host-pathogen interaction, showing that impaired recycling affects virulence and immune activation in Drosophila.

bioRxiv · Jul 3, 2023 · PreprintMicrobiology

Sex-specific deubiquitylation drives immune-related neurodegeneration in Drosophila

J. Xia, A. Pinto-Fernandez, A. Damianou, J. Lee, B. M. Kessler, I. Davis, P. R. Elliott, P. Ligoxygakis

This study shows that sex-specific deubiquitylation by Trabid in Drosophila influences neurodegeneration linked to immune responses and protein accumulation.

bioRxiv · Dec 9, 2022 · PreprintImmunology

HYD3, a conidial hydrophobin of the fungal entomopathogen Metarhizium acridum induces the immunity of its specialist host locust

Z. Jiang, P. Ligoxygakis, Y. Xia

This study shows that the hydrophobin HYD3 from the specialist fungal pathogen Metarhizium acridum activates immunity in its host locust but not in non-host insects.

International Journal of Biological Macromolecules · Dec 1, 2020Peer-reviewedMicrobiology

Tools for the genetic manipulation of Herpetomonas muscarum

M. A. Sloan, P. Ligoxygakis

This paper describes genetic manipulation tools for Herpetomonas muscarum to study insect-parasite interactions in a model dipteran system.

G3 Genes|Genomes|Genetics · May 1, 2020Peer-reviewedMicrobiology

From pathogen to commensal to probiotic: modification of Microbacterium nematophilum-C. elegans interaction during chronic infection by the absence of host insulin signalling

M. J. Gravato-Nobre, J. Hodgkin, P. Ligoxygakis

This study investigates how the absence of host insulin signaling in C. elegans alters the interaction with Microbacterium nematophilum, converting a pathogen to a commensal and probiotic.

bioRxiv · Apr 1, 2020Immunology

The Phlebotomus papatasi transcriptomic response to trypanosomatid-contaminated blood is robust but non-specific

M. A. Sloan, J. Sadlova, T. Lestinova, M. Sanders, J. A. Cotton, P. Volf, P. Ligoxygakis

The paper examines the transcriptomic response of sand flies to trypanosomatid-contaminated blood, finding a generalized response to blood meals rather than specific parasite-related changes.

bioRxiv · Dec 6, 2019 · PreprintImmunology

Transcriptional and genomic parallels between the monoxenous parasite Herpetomonas muscarum and Leishmania

M. A. Sloan, K. Brooks, T. D. Otto, M. J. Sanders, J. A. Cotton, P. Ligoxygakis

This paper compares the genome and transcriptome of the monoxenous trypanosomatid Herpetomonas muscarum with the dixenous parasite Leishmania during insect infection, finding conserved features in host interaction.

bioRxiv · Jul 4, 2019Microbiology

Drosophila Toll links systemic immunity to long-term intestinal epithelial integrity

M. Atilano, M. Glittenberg, S. Bahuguna, L. Wang, P. Ligoxygakis

This study shows that the Drosophila Toll pathway regulates intestinal epithelial integrity by controlling 4E-BP and fat levels in response to infection and microbiota.

bioRxiv · Dec 20, 2018 · PreprintImmunology

Intestinal NF-κB and STAT signalling is important for uptake and clearance in a Drosophila-Herpetomonas interaction model.

L. Wang, M. Sloan, P. Ligoxygakis

This study investigates the role of NF-κB and STAT signaling in Drosophila's response to Herpetomonas infection, showing their importance in parasite clearance and intestinal dynamics.

bioRxiv · Jun 20, 2018Immunology

A host-pathogen interaction screen identifies ada2 as a mediator of Candida glabrata defences against reactive oxygen species

I. Kounatidis, L. Ames, R. Mistry, H.-l. Ho, K. Haynes, P. Ligoxygakis

This study identifies ADA2 as a key mediator of Candida glabrata's resistance to reactive oxygen species in host defense.

bioRxiv · Jan 17, 2018Microbiology