Author

P. Sicinski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Animal Behavior & Cognition· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:behavioral assay· 1 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. A. Wang· 1 shared A. Fernandez· 1 shared A. Thomas· 1 shared B. Lemmers· 1 shared B. Liss· 1 shared B. Miwatani-Minter· 1 shared B. Ueberheide· 1 shared C. G. Piett· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCell Biology

A. A. Wang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability

G. Rona, B. Miwatani-Minter, Q. Zhang, H. V. Goldberg, M. A. Kerzhnerman, J. B. Howard, D. Simoneschi, E. Lane, J. W. Hobbs, E. Sassani, A. A. Wang, S. Keegan, D. J. Laverty, C. G. Piett, L. S. Pongor, , M. Pagano

This study shows D-type cyclins inhibit mismatch repair (MMR) in G1 phase by shielding p21, while their degradation in S phase enables proper MMR function, maintaining genome stability.

bioRxiv · Jan 12, 2024Cell Biology

Loss of cyclin A2 in murine colonic epithelial cells disrupts colon homeostasis by triggering DNA damage and dysplasia and high cyclin A2 expression is a good-prognosis factor in patients with colorectal cancer

Y. Guo, M. Gabola, R. Lattanzio, C. Paul, V. Pinet, R. Tang, H. Tulari, J. Bremond, C. Maurizy, Q. Da Costa, P. Finetti, F. Boissiere-Michot, C. Lemmers, S. Garnier, F. Bertucci, , M. Hahne

This study shows that loss of cyclin A2 in colonic epithelial cells causes DNA damage, dysplasia, and colon inflammation, while high cyclin A2 expression is linked to better prognosis in colorectal cancer.

bioRxiv · Jul 3, 2019 · PreprintCancer Biology

Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27

J. Leon, L. Garcia-Gutierrez, G. Bretones, E. Molina, I. Arechaga, J. C. R. Acosta, R. Blanco, A. Fernandez, L. Alonso, P. Sicinski, M. Barbacid, D. Santamaria

The paper shows Myc activates Cdk1 to phosphorylate p27 at Thr187, promoting its degradation and cell cycle progression, with Cdk1 inhibition causing synthetic lethality with Myc.

bioRxiv · Dec 16, 2018Cancer Biology

Schizophrenia-related cognitive dysfunction in the Cyclin-D2 knockout mouse model of ventral hippocampal hyperactivity

C. M. Grimm, S. Aksamaz, S. Schulz, J. Teutsch, P. Sicinski, B. Liss, D. Kaetzel

This study evaluates cognitive dysfunction in Cyclin-D2 knockout mice, finding impaired executive function and working memory linked to hippocampal over-activity in a schizophrenia model.

bioRxiv · May 14, 2018Animal Behavior & Cognition