J.-J. Chung

DHCR24-mediated sterol homeostasis during spermatogenesis is required for sperm mitochondrial sheath formation and impacts male fertility over time

LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility

This study identifies LRRC23 as a critical component of the RS3 head in mammalian sperm, showing that its truncation leads to defective flagellar motility and male infertility.

A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking

This study identifies CATSPER{theta} as essential for CatSper channel assembly in sperm flagella, revealing its role in channel formation and flagellar trafficking, leading to male infertility in its absence.

TXNRD3 supports male fertility via the redox control of spermatogenesis

This study shows TXNRD3 is essential for male fertility by regulating redox balance during spermatogenesis, as demonstrated through knockout mice and proteomic analysis.

C2cd6-encoded CatSper{tau} Targets Sperm Calcium Channel to Ca2+ Signaling Domains in the Flagellar Membrane

This study identifies CatSper{tau}, a C2cd6-encoded protein, as a critical targeting component for the CatSper Ca2+ channel to the flagellar Ca2+ signaling nanodomains, essential for sperm motility and fertility.

Redox regulation by TXNRD3 during epididymal maturation underlies capacitation-associated mitochondrial activation and sperm motility in mice

This study identifies TXNRD3's role in redox regulation during epididymal maturation, showing its impact on mitochondrial function and sperm motility in mice.

3D structure and in situ arrangements of CatSper channel in the sperm flagellum

This study uses cryo-electron tomography to reveal the 3D structure and arrangement of the CatSper channel complex in mammalian sperm, identifying new associated proteins and structural features critical for flagellar function.

3D in situ imaging of female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice

The paper uses 3D in situ imaging to identify molecular features of fertilizing sperm in mice, showing intact CatSper channels, lack of phosphorylation, and reacted acrosomes.

EFCAB9 is a pH-Dependent Ca2+ Sensor that Regulates CatSper Channel Activity and Sperm Motility

This study identifies EFCAB9 as a pH-dependent Ca2+ sensor that modulates CatSper channel activity and sperm motility through its interaction with CATSPERζ.