Author

J. Y. Hwang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 1 Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Organism:mouse· 7 Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Research Focus:development & morphogenesis· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

J.-J. Chung· 6 shared H. Wang· 3 shared S. Gygi· 2 shared A. A. Turanov· 1 shared B. Alejandro· 1 shared C. R. Carroll· 1 shared C. Wiesehoefer· 1 shared D. Chung· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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6 shared papersCell Biology

J.-J. Chung

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Author profile →

8 papers

Recent·Most cited

LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility

J. Y. Hwang, P. Chai, S. Nawaz, J. Choi, F. Lopez-Giraldez, S. Hussain, K. Bilguvar, S. Mane, R. P. Lifton, W. Ahmad, K. Zhang, J.-J. Chung

This study identifies LRRC23 as a critical component of the RS3 head in mammalian sperm, showing that its truncation leads to defective flagellar motility and male infertility.

eLife · Dec 13, 2023Peer-reviewedCell Biology

Non-catastrophic collapse of VEEV by lethal mutagenesis

B. Alejandro, E. J. Kim, J. Y. Hwang, J. W. Park, M. Smith, D. Chung

This study investigates how Venezuelan Equine Encephalitis Virus (VEEV) responds to RNA mutagen treatment, finding that replication-competent subpopulations persist with lower mutation frequency and increased adaptability.

bioRxiv · Jun 21, 2022 · PreprintMicrobiology

TXNRD3 supports male fertility via the redox control of spermatogenesis

Q. Dou, A. A. Turanov, M. Mariotti, J. Y. Hwang, H. Wang, S.-G. Lee, J. A. Paulo, S. H. Yim, S. Gygi, J.-J. Chung, V. N. Gladyshev

This study shows TXNRD3 is essential for male fertility by regulating redox balance during spermatogenesis, as demonstrated through knockout mice and proteomic analysis.

bioRxiv · Dec 29, 2021 · PreprintBiochemistry

C2cd6-encoded CatSper{tau} Targets Sperm Calcium Channel to Ca2+ Signaling Domains in the Flagellar Membrane

J. Y. Hwang, H. Wang, Y. Lu, M. Ikawa, J.-J. Chung

This study identifies CatSper{tau}, a C2cd6-encoded protein, as a critical targeting component for the CatSper Ca2+ channel to the flagellar Ca2+ signaling nanodomains, essential for sperm motility and fertility.

bioRxiv · Aug 16, 2021Cell Biology

3D structure and in situ arrangements of CatSper channel in the sperm flagellum

Y. Zhao, H. Wang, C. Wiesehoefer, N. B. Shah, E. Reetz, J. Y. Hwang, X. Huang, P. V. Lishko, K. M. Davies, G. Wennemuth, D. Nicastro, J.-J. Chung

This study uses cryo-electron tomography to reveal the 3D structure and arrangement of the CatSper channel complex in mammalian sperm, identifying new associated proteins and structural features critical for flagellar function.

bioRxiv · Jun 19, 2021Biophysics

3D in situ imaging of female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice

L. Ded, J. Y. Hwang, K. Miki, H. F. Shi, J.-J. Chung

The paper uses 3D in situ imaging to identify molecular features of fertilizing sperm in mice, showing intact CatSper channels, lack of phosphorylation, and reacted acrosomes.

bioRxiv · Aug 14, 2020Cell Biology

Neuropilin-1 regulates the secondary CD8 T cell response to virus infection

J. Y. Hwang, Y. Sun, C. R. Carroll, E. J. Usherwood

This paper shows that neuropilin-1 affects the secondary CD8 T cell response to virus infection, with timing of deletion influencing outcomes in persistent viral infections.

bioRxiv · Apr 11, 2019Immunology

EFCAB9 is a pH-Dependent Ca2+ Sensor that Regulates CatSper Channel Activity and Sperm Motility

J. Y. Hwang, N. Mannowetz, Y. Zhang, R. A. Everley, S. Gygi, J. Bewersdorf, P. Lishko, J.-J. Chung

This study identifies EFCAB9 as a pH-dependent Ca2+ sensor that modulates CatSper channel activity and sperm motility through its interaction with CATSPERζ.

bioRxiv · Nov 1, 2018Cell Biology